鈻庤嵂鏄庡悍寰峰唴瀹瑰洟闃熺紪杈?/strong>
鏈€杩戯紝鍝堜經鍖诲闄㈢殑鐮旂┒鑰呭湪銆婄粏鑳炪€嬩笂鍙戣〃浜嗕竴绡囬噸纾呰鏂囷紝鐮旂┒鎵惧埌浜嗕釜浣撹“鑰佺殑鍏抽敭褰卞搷鍥犵礌銆傛垜浠繃鍘诲彲鑳借涓篋NA鐨勫彉鍖栨槸琛拌€佷骇鐢熺殑鏈€涓昏鍘熷洜锛岀劧鑰屾柊鐮旂┒鍑犱箮鎺ㄧ炕浜嗚繖涓€鎺ㄦ祴锛屾牴鎹粬浠殑鏁版嵁锛?strong>DNA鍙樺寲涓嶄絾涓嶆槸鍞竴锛岀敋鑷充笉鏄富瑕佺殑琛拌€佸師鍥犮€?/strong>
鐪熸璧蜂綔鐢ㄧ殑鏄偅浜涘奖鍝岲NA缁撴瀯銆佽皟鎺NA琛ㄨ揪鐨勫垎瀛愶紝涔熷氨鏄父璇寸殑琛ㄨ閬椾紶鍒嗗瓙銆?strong>涓€鏃﹁〃瑙傞仐浼犻€€鍖栵紝琛拌€佹墠浼氱湡姝e湴鏉ヤ复銆?/strong>
鎸夌収杩囧幓鐨勬帹娴嬶紝闅忕潃涓綋骞撮緞鐨勫闀匡紝DNA鏇村鏄撶疮绉熀鍥犵獊鍙樼瓑瀵艰嚧鐨勯敊璇彉鍖栵紝杩欎簺鍙樺寲浼氬奖鍝嶅熀鍥犳椿鎬э紝鏈€鍚庝娇缁嗚優銆佺粍缁囧姛鑳藉け甯革紝杩欎篃鏄“鑰佺殑閲嶈浣撶幇銆?/p>
浣嗘槸涓€浜涚爺绌跺彂鐜版晠浜嬪苟闈炲姝ょ畝鍗曪紝姣斿鏈変簺灏忛紶鍜屼汉绫绘偅鑰呮嫢鏈夐珮浜庡钩鍧囩殑绐佸彉姘村钩锛屼絾鏄繖浜涗釜浣撳苟娌℃湁琛ㄧ幇鍑烘棭琛扮殑杩硅薄銆傝繖浜涚粨鏋滆〃鏄庡熀鍥犲彉鍖栫殑浣滅敤鏈夐檺锛屼簬鏄疍avid Sinclair鏁欐巿鍥㈤槦寮€濮嬪皢琛ㄨ閬椾紶绾冲叆鑰冭檻鑼冪暣銆?/p>
琛ㄨ閬椾紶鍒嗗瓙鍙互鍏呭綋鍩哄洜娲绘€х殑寮€鍏筹紝瀹冧滑鍙互閫氳繃褰卞搷鏌撹壊浣撶粨鏋勫喅瀹氬熀鍥犵殑琛ㄨ揪娲绘€с€傛棭鍦?0骞村墠锛孲inclair鏁欐巿灏卞湪閰垫瘝鑿屼腑鍙戠幇琛ㄨ閬椾紶鍙樺寲涓庤“鑰佹槸鍚屾鐨勩€?/p>
鍥剧墖鏉ユ簮锛?23RF
鍦ㄦ渶鏂扮殑璁烘枃涓紝浠栦滑灏嗙爺绌跺璞℃墿灞曞埌浜嗗皬榧犺韩涓婏紝鐮旂┒鑰呯粰灏忛紶鐨凞NA寮曞叆涓€浜涙殏鏃舵€т笖鑳藉揩閫熶慨澶嶇殑鍒囧彛锛岃繖浜涚粏寰殑鎹熶机鍙互妯℃嫙鎴戜滑鏃ュ父鎵€閬囧埌鐨勬儏鍐碉紝姣斿绱绾裤€佸寲瀛﹀垎瀛愬拰鑷敱鍩烘崯浼ょ瓑銆?/p>
涓轰簡鏇村ソ鍦拌拷韪“鑰佸彉鍖栵紝鐮旂┒鑰呭鍔犱簡DNA鍒囧彛寮曞叆鐨勯鐜囷紝骞朵笖杩欎簺鍒囧彛涓嶄細鍑虹幇鍦―NA缂栫爜鍖猴紝鍥犳涓嶄細閫犳垚铔嬬櫧鏀瑰彉锛屼絾鍒囧彛浼氭敼鍙楧NA鎶樺彔銆?/p>
鏍规嵁瑙傚療锛岃〃瑙傞仐浼犲垎瀛愪細鏆傛椂鍋滄璋冩帶鍩哄洜鐨勫伐浣滐紝杞ご杩佺Щ鍒板垏鍙i檮杩戝府鍔╁畬鎴怐NA淇锛岄殢鍚庝細杩斿洖鍒板師濮嬬殑浣嶇疆缁х画鏈亴宸ヤ綔銆?/p>
杩欑鎯呭喌涓€娆′袱娆¤繕濂斤紝闅忕潃鏃堕棿鎺ㄧЩ锛孌NA鍒囧彛鍑虹幇鐨勬儏鍐靛彉澶氾紝琛ㄨ閬椾紶鍒嗗瓙寮€濮嬮€愭笎鍒嗗績锛屽畠浠幓寰€鍒囧彛瀹屾垚淇宸ヤ綔鍚庝笉鍐嶈繑鍥炲師鏉ョ殑浣嶇疆銆傝繖鎰忓懗鐫€锛?strong>琛ㄨ閬椾紶鍙樺緱澶卞幓缁勭粐锛屽師鏈渶瑕佽皟鑺傜殑DNA涔熷浜庡け鎺х姸鎬併€?/strong>
鐮旂┒鑰呮寚鍑鸿繖鏄吀鍨嬬殑琛ㄨ閬椾紶澶辫皟锛岄暱姝や互寰€锛屾煋鑹蹭綋浼氬彉寰楁洿鑷村瘑锛岄毦浠ヨВ寮€銆?/p>
鈻茬爺绌剁ず鎰忓浘锛堝浘鐗囨潵婧愶細鍙傝€冭祫鏂橻1]锛?/strong>
杩欑鍩哄洜灞傞潰鐨勫紓甯镐細浣垮緱灏忛紶澶卞幓鍘熸湰骞磋交鏃剁殑琛ㄨ閬椾紶鍔熻兘锛岀洿瑙傜殑琛ㄧ幇灏辨槸灏忛紶鐪嬭捣鏉ユ瘮鍚岄緞姝e父灏忛紶鏇磋€侊紝琛屽姩涔熸洿鍍忚€佸勾灏忛紶銆傞櫎姝や箣澶栵紝鐮旂┒鑰呭彲浠ュ湪瀹為獙灏忛紶涓娴嬪埌閫愭笎鍗囬珮鐨勮“鑰佹爣蹇楃墿锛屼笌姝ゅ搴旂殑锛屽畠浠殑鐢熺墿瀛﹀勾榫勪篃姣斿悓榫勫仴搴峰皬榧犳洿澶с€?/p>
浠庢椂闂翠笂鏉ョ湅锛岃繖浜涘疄楠屽皬榧犱粎鍦?涓湀澶х殑鏃跺€欏氨浼氬嚭鐜拌“鑰佽抗璞★紝鑰屾甯稿皬榧犱細鍦ㄧ害涓ゅ瞾鏃舵墠鍑虹幇銆?/p>
褰撶劧锛孲inclair鏁欐巿鎸囧嚭杩欑琛ㄨ閬椾紶澶辫皟寮曡捣鐨勮“鑰?strong>骞堕潪涓嶅彲閫?/strong>锛屼粬浠嫭鍒涗簡涓€绉嶅熀鍥犵枟娉曪紝鍏朵腑鍖呮嫭3绉嶅共缁嗚優娲昏穬鐨勫熀鍥燨ct4銆丼ox2 鍜?Klf4銆?strong>杩欑鍩哄洜鐤楁硶鍙互甯姪瀹為獙灏忛紶鐨勭粏鑳炴仮澶嶅埌骞磋交鐨勭姸鎬侊紝瀹冧滑浼间箮鍙互璁╄〃瑙傞仐浼犲け璋冪殑缁嗚優閲嶆柊鍚姩銆?/strong>
杩欎篃涓烘仮澶嶇粏鑳炴椿鍔涳紝鎺у埗琛拌€佹彁渚涗簡鏂扮殑鎬濊矾銆係inclair鏁欐巿鎸囧嚭锛屼粬浠殑鐩爣鏄В鍐宠“鑰佷互鍙婅“鑰侀檮甯︾殑鐤剧梾锛屼竴涓汉涓嶄粎鍙互娲荤潃锛岃繕鍙互淇濇寔鍋ュ悍锛岃繖鎵嶆槸鏈€缁堢殑搴旂敤鐩殑銆?/p>
鍙傝€冭祫鏂欙細
[1] Jae-Hyun Yang et al, Loss of epigenetic information as a cause of mammalian aging, Cell (2023). DOI: 10.1016/j.cell.2022.12.027
[2] Loss of epigenetic information can drive aging, restoration can reverse it. Retrieved January 13, 2023 from https://medicalxpress.com/news/2023-01-loss-epigenetic-aging-reverse.html