涓汉瑙傜偣锛屼笉浠ｈ〃浠讳綍缁勭粐涓庡崟浣?/strong>
鍖讳繚闆嗛噰璋堝垽鐮翠緥鎻愬墠瀹ｅ竷浜嗘渶鍙楀叧娉ㄧ殑鏂板啝鑽墿璋堝垽缁撴灉锛氳緣鐟炵殑Paxlovid鍥犱负浠锋牸闂娌¤皥鎴愶紝闃垮吂澶畾涓庢竻鑲烘帓姣掗绮掕皥鎴愪簡銆?/p>
1. 涓轰粈涔堝叧娉≒axlovid鐨勯泦閲囷紵
涓変釜閲屽摢涓湁鍚噾閲忥紝鍝袱涓槸浠€涔堣揣鑹擦ぇ瀹跺績鐭ヨ倸鏄庛€傚湪閲嶇棁楂樺嘲涔嬮檯锛屾暣涓尰淇濋泦閲囩湡姝ｅ叏姘戝叧娉ㄧ殑涔熷氨鏄疨axlovid銆傜敋鑷冲彲浠ヨ繖涔堣锛屾墍鏈夊幓璋堥泦閲囩殑鑽紝鏈夌粷瀵规皯鎰忔敮鎸侊紝甯屾湜鑳借皥鎴愮殑锛屼篃灏辨槸Paxlovid銆?/p>
寰堝璐㈢粡鍙ｃ€佸尰鑽彛鐨勮鑰呴兘鍦ㄨ共鐐归泦閲囷紝姣旇緝閬楁喚濂藉儚娌℃湁鍝綅鎯崇潃鍋氫釜姘戞剰璋冩煡锛岄棶闂幓鍙傚姞鐨勮澶氳嵂浼佷唬琛ㄤ滑锛屽Paxlovid璋堝垽鏄粈涔堟湡寰呫€傚鏋滃仛浜嗚繖涓皟鏌ワ紝鐩镐俊澶ч儴鍒嗕細鏄笇鏈涜繖涓嵂鑳借皥鎴愩€傚墿涓嬬殑鍖呮嫭鍑犱釜PD-1鎶椾綋锛屽嚑涓珵浜夊鎵嬩箣闂达紝鎭愭€曞反涓嶅緱鑷繁璋堟垚锛屽埆浜鸿皥涓嶆垚锛岃€佺櫨濮撴洿鏄及璁¤皝鏄皝閮戒笉璁よ瘑锛岃皝璋堝緱鎴愯皥涓嶆垚涔熶笉鍦ㄦ剰銆?/p>
涓轰粈涔堝ぇ瀹跺笇鏈汸axlovid鑳借皥鎴愶紵鍥犱负杩欏畠瀵规柊鍐犳湁鏄庣‘鐨勪綔鐢紝鑰屽湪鐤儏涓嬫垜浠張鏈夋樉钁楃殑闇€姹傘€傚緢澶氫汉鍙兘瀵瑰尰淇濋泦閲囨湁璇В锛屾病璋堟垚鐨勮嵂涓嶆槸璇村氨杩涗笉浜嗗浗闂紝鐢ㄤ笉浜嗐€傚彲鏄潰瀵瑰北鍛兼捣鍟哥殑鏂板啝鎰熸煋锛孭axlovid鍦ㄥ浗鍐呯殑渚涘簲涓€鐩村浜庢瀬涓虹揣寮犵敋鑷虫贩涔辩殑鐘舵€併€?strong>甯屾湜Paxlovid杩涘尰淇濓紝涓嶄粎鏄垨鑰呰涓嶆槸鎯崇潃杩欎釜鑽兘闄嶄环锛岃€屾槸甯屾湜杩涗簡鍖讳繚涔嬪悗锛岃繖涓嵂鐨勪緵搴旇兘澶熷緱鍒颁繚闅滐紝鎰熸煋浜嗕箣鍚庣鍚堟潯浠垛€斺€旈噸鐥囬闄╅珮鐨勪汉鑳藉強鏃剁敤涓?/strong>銆?/p>
瀵癸紝鑰佺櫨濮撴兂鐨勬槸鏈夎嵂鍙敤銆傝繖涓€鐐瑰尰淇濋泦閲囧簲璇ヤ篃蹇冪煡鑲氭槑锛屾墍浠ヨPaxlovid娌¤皥鎴愭椂椤轰究鍙堣浜嗛樋鍏瑰か瀹氬拰娓呰偤鎺掓瘨棰楃矑璋堟垚浜嗭紝澶ф涔熸槸鐭ラ亾鍚庝袱涓粈涔堟垚鑹诧紝鍙堣繘涓€姝ヨ娑夊強鏂板啝杩樻湁600澶氫釜鑽墿鍦ㄥ尰淇濆悕褰曘€?/p>
浣嗚繖灏辨槸鍋锋崲姒傚康浜嗐€傞€氳繃鍙岀洸璇曢獙浠ュ強鐪熷疄涓栫晫妫€楠岋紝鐪熸鑳介拡瀵规柊鍐狅紝闄嶄綆閲嶇棁椋庨櫓鐨勶紝杩欎簺鑽墿閲屽彧鏈塒axlovid锛屾妸600澶氫釜鑽姞杩涙潵锛岄偅鏄妸鍚勭閫€鐑ц嵂姝㈠挸鑽兘绠椾笂銆傝繖鏈夋剰涔夊悧锛熼毦閬撳拰鍖婚櫌閲岀劍澶寸儌棰濈殑鍖绘姢浜哄憳璇达細涓嶈鎱岋紝铏界劧娌℃湁Paxlovid鏉ラ檷浣庢劅鏌撶殑鑰佺櫨濮撶殑閲嶇棁椋庨櫓锛堝洜姝や細鏈夋洿澶氫汉瑕佷綇闄級锛屼絾閫€鐑ц嵂鍖讳繚浼氭姤閿€锛?/p>
2. 闈㈠鍏崼鍗辨満锛屽尰淇濆幓璋堝氨鏄敊浣?/strong>
鍥犳锛屽綋闆嗛噰鎶涘嚭鈥滀环閽辨病璋堟嫝鈥濓紝鑰屽獟浣撶悍绾锋彛娴嬮泦閲囧簳绾垮灏戯紝杈夌憺鍙効鎰忛檷浠峰灏戞椂锛屾垜浠棭宸擦亸绂讳簡Paxlovid鏈繘鍖讳繚闆嗛噰鐨勫叧閿棰橈細濡備綍淇濋殰鍥戒汉鑳界敤涓婁竴涓槑纭湁鏁堬紝鍙堟湁鍒囧疄闇€姹傜殑鑽墿銆?/p>
浠庤繖涓搴﹀嚭鍙戯紝鍖讳繚闆嗛噰Paxlovid鏈韩灏辨湁涓嶆伆褰撲箣澶勩€傞泦閲囧け璐ュ悗锛屼笉灏戜汉寮€濮嬫敞鎰忓埌鍥藉鐨凱axlovid閲囪喘浠疯繙楂樹簬涔嬪墠涓浗鐨勫尰淇濋噰璐环銆傚尰淇濆畾浠蜂箣鍓嶆槸2300浜烘皯甯佷竴鐤楃▼锛屾渶杩戞嵁濯掍綋鎶ラ亾涓嬮檷鍒?890浜烘皯甯併€傝€岀編鍥芥斂搴滅璁㈢殑鍚堝悓鏄?30缇庡厓涓€鐤楃▼銆傛娲蹭互鍙婃棩鏈境澶у埄浜氱瓑鍥界殑閲囪喘浠蜂篃娌℃湁涓庣編鍥界殑浠锋牸鍋忕澶銆傚疄闄呬笂缇庡浗鏀垮簻閲囪喘鍚堝悓鍖呮嫭浜嗕竴椤瑰彂杈惧浗瀹朵环鏍间繚璇佹潯娆撅紝鏃ユ湰寰峰浗绛?涓彂杈惧浗瀹跺鏋滈噰璐环鏍间綆浜庣編鍥斤紝缇庡浗鐨勫悎鍚屼細鑷姩鏇存柊涓鸿繖涓洿浣庣殑浠锋牸銆?/p>
杩欎簺鏁版嵁閮芥槸鍏紑鐨勶紝鏄剧劧杈夌憺娌℃湁瑕佸悜涓浗澶氭敹閽便€傚疄闄呬笂璺ㄥ浗鑽紒鐨勫叏鐞冨畾浠蜂笌鍚勫湴缁忔祹鍙戝睍銆佷汉鍧囨敹鍏ユ寕閽┿€傚彧瑕佹槸涓浗姝ｅ紡涓婂競鐨勮嵂鍝侊紝鍦ㄨ繖鏍蜂竴涓畾浠蜂綋绯诲唴蹇呯劧姣斿彂杈惧浗瀹舵洿渚垮疁銆?/p>
浣嗘洿涓哄叧閿殑闂鏄叾瀹冨浗瀹剁殑閲囪喘浠蜂笉鏄尰鐤椾繚闄╃殑鍗忓晢浠锋牸锛?strong>鏄斂搴滃湪澶ф祦琛岃儗鏅笅涓哄叕鍗嵄鏈烘墍鍋氱殑鍏抽敭鐗╄祫閲囪喘銆傝繖姣斾环鏍兼瘮杈冩洿涓哄叧閿紝涔熸槸涓轰粈涔堟垜璇村尰淇濆幓闆嗛噰Paxlovid鏈韩灏变笉鍚堥€傘€?/p>
鍏崼鍗辨満鏈夌揣鎬ユ€э紝鑰屽尰淇濅綔涓轰竴绉嶅尰鐤椾繚闄╋紝瑕嗙洊鐨勮嵂鐗╄鑰冭檻闀挎湡鐨勪緵姹傘€傚綋涓嬩腑鍥藉浜庣柅鎯呴珮宄版湡锛孭axlovid鐨勯噰璐槑鏄炬槸闇€瑕佹妸鐫€鐪肩偣鏀惧湪鍏崼鍗辨満涓婏紝姝ゆ椂鎸夊尰鐤椾繚闄╄皥锛屾€濊矾灏卞緢濂囨€€?/p>
鎴栬涔熸槸涓轰簡婊¤冻鐪间笅鏂板啝鐤儏鐨勭揣鎬ョ姸鎬侊紝鍖讳繚闆嗛噰澶辫触鍚庡悓鏃惰〃鎬佷細缁х画鏀粯鍒?鏈?1鏃ャ€傚彲杩欎粛鐒跺洖閬夸簡鐪熸鐨勫叧閿棶棰橈細濡備綍淇濊瘉Paxlovid杩欎釜鐤儏鏆村彂鍚庨檷浣庨噸鐥囥€佹浜＄殑鍏抽敭鐗╄祫鐨勪緵搴?/strong>銆?/p> 闂涓嶆槸鍖讳繚鎰挎剰缁х画浠橀挶鍒颁粈涔堟椂鍊欙紝浠ュ強鎰挎剰浠樺灏戦挶锛岃€屾槸鍒板簳鎵嬩笂鏈夊灏戣嵂锛屾墦绠椾拱澶氬皯鑽紝璁╁灏戜汉鏈€鍚庤兘鐢ㄤ笂鑽紝璁╁摢浜涗汉鐢ㄤ笂鑽€傝繖浜涢棶棰橀毦閬撹褰掑尰淇濇垨鍖讳繚闆嗛噰绠″悧锛?/p> 鍗充究鏄柅鎯呭凡缁忚繘鍏ョǔ瀹氭湡鐨勫彂杈惧浗瀹讹紝Paxlovid杞悜鍟嗕笟淇濋櫓鐨勮繍浣滈兘鏈紑濮嬶紝鐜颁笅鍋氬尰淇濋泦閲囷紝鏈韩鏄惁鏄竴绉嶉敊浣嶏紵 3.聽鍏ㄧ悆璁ゅ彲Paxlovid浠峰€肩殑鍩虹 浠呬粎鏄?022骞村墠涓変釜瀛ｅ害锛孭axlovid鐨勫叏鐞冮攢鍞灏辫揪鍒颁簡170浜跨編鍏冦€傛樉鐒惰繖涓嵂鍦ㄥ叏鐞冭幏寰椾簡浠峰€艰鍚岋紝涔熷氨鏄鍏ㄧ悆寰堝涓浗瀹惰涓哄€煎緱浠樺嚭閭ｄ箞楂樼殑閲戦锛屽幓涔板畠銆?/p> 鍓嶆枃宸茬粡璇翠簡锛屽叕寮€鐨勫悇鍥芥斂搴滈噰璐环閮芥瘮鍖讳繚閲囪喘浠锋洿楂樸€傝璁篜axlovid鍗栧緱璐垫垨渚垮疁锛屼笉鑳藉厜鐪嬫爣浠凤紝鑰岃鐪嬩环鍊笺€傚惁鍒欎綘鏁村ぉ鎸囩潃鍗栭珮妗ｇ墰鎺掔殑璐ㄩ棶浜哄鎬庝箞涓€鏂よ倝姣斾竴鏂ょ櫧鑿滆吹锛屼笉鏄剳瀛愭湁鐥呭悧锛?/p> 闈炲父鐜板疄鐨勪竴鐐癸細Paxlovid鏄洰鍓嶆墍鏈夋柊鍐犳姉鐥呮瘨鑽墿涓紝鏈夋晥鎬у畨鍏ㄦ€ф€讳綋鏈€濂斤紝浣跨敤鏈€涓轰究鎹风殑閫夋嫨銆?/p> 浠庢湁鏁堟€ф潵鐪嬶紝Paxlovid鍦ㄦ湭鎺ョ鐤嫍鐨勯珮鍗变汉缇や腑鍙檷浣庝綇闄笌姝讳骸椋庨櫓89%锛堜笁鏈熶复搴婅瘯楠岋級锛屾帴绉嶈繃鐤嫍鐨勯珮鍗变汉缇わ紝闄嶄綆浣忛櫌椋庨櫓68%锛堜互鑹擦垪鐪熷疄涓栫晫鐮旂┒锛夈€傝繖涓瘮鍒氳繘鍏ヤ腑鍥界殑榛樺厠鍙ｆ湇鑽珮寰堝銆備竴浜涘垎鏋愯榛樺厠鐨勫彛鏈嶈嵂杩涙潵浜嗭紝鏈夌珵浜変簡锛屽尰淇濅笉鐢ㄦ€ョ潃涔癙axlovid銆傚仛杩欑鍒嗘瀽鐨勪汉锛岃繛鑽墿鏈夋晥鎬х殑宸紓閮戒笉鎳傘€?/p> 浠庡畨鍏ㄦ€х湅锛孭axlovid涓嶄粎涓夋湡涓村簥璇曢獙鎷涘嫙瓒呰繃涓ゅ崈浜猴紝涓婂競鍚庡叏鐞冪敤浜嗙殑浜哄ぇ姒傚湪鍗冧竾绾у埆銆?strong>杩欐槸澶ч噺鐨勫畨鍏ㄦ€ф暟鎹Н绱?/strong>銆傛湁浜涗汉璇存煇鏌愬湪鐮旂殑鑽浣曞浣曪紝閮戒笉璇磋繖鍦ㄧ爺鐨勪粈涔堟椂鍊欑爺绌跺畬涓嶅ソ璇达紝浠ュ強鐮旂┒鍑烘潵鍟ユ牱闅捐锛屽氨绠楃瓑閭ｈ嵂鎵逛簡锛岃儗鍚庣殑瀹夊叏鎬ф暟鎹槸澶氬皯锛熻嵂鐗╀笉鑹弽搴斾腑锛屼笉甯歌鐨勫畾涔夋槸鍙戠敓鐜囧湪鐧惧垎涔嬩竴鍒板崈鍒嗕箣涓€锛岀綍瑙佹槸鍗冨垎涔嬩竴鍒颁竾鍒嗕箣涓€銆傛寜杩欎釜鏍囧噯锛屽浗鍐呭湪鐮旂殑鏂板啝鎶楃梾姣掕嵂鏈夊嚑涓兘鏄庣‘缃曡涓嶈壇鍙嶅簲锛屼笉甯歌鐨勯兘鏈繀鑳芥壘鍏ㄥ惂锛烿V116鍋氱殑澶村澶磋瘯楠岄噷鐢ㄤ簡VV116鐨勪笉鍒?00浜猴紝杩欎釜鏁版嵁閲忚兘璇碫V116瀹夊叏鎬ф洿濂斤紵 渚挎嵎鎬т笂鍙ｆ湇鑽殑浼樺娍鏇翠笉蹇呰銆傛€荤粨涓嬫潵锛?strong>Paxlovid鏄洰鍓嶅畨鍏ㄦ€ф暟鎹Н绱渶澶氾紝瀵归珮鍗变汉缇ゆ潵璇翠篃鏄劅鏌撳悗闄嶄綆閲嶇棁椋庨櫓鏈€鍙潬鐨勪竴涓€夋嫨
4.聽闂嵂鍊煎灏戦挶锛屾兂鎯充汉鍊煎灏戦挶
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鑰屽浠婇噸鐥囬珮宄颁笅璁ㄨPaxlovid搴旇鍊煎灏戦挶锛屼笉濡傞棶涓€涓嬩竴鏉″懡鍊煎灏戦挶銆?/p>
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澶忓BA.5楂樺嘲鏈?5宀佷互涓婅€佷汉姣忓崄涓囦汉绾︽湁1000浜哄湪鐢≒axlovid锛屾牴鎹繖浜涗及璁″浠婄編鍥界‘璇婃柊鍐犵殑鎰熸煋鑰呴噷瓒呰繃涓夊垎涔嬩竴鐢ㄤ簡Paxlovid銆傚嵆渚垮姝わ紝缇庡浗浠嶇劧璁や负杩欎釜鑽殑鎺ㄥ箍杩樹笉澶熴€傛瘮濡備竴浜涘皯鏁版棌瑁斾娇鐢ㄥ亸灏戯細
闈炶65-79宀佽€佷汉涓彧鏈?4%鐨勬劅鏌撹€呭湪4-7鏈堢敤浜哖axlovid銆傚浗鍐呯幇鍦ㄩ珮鍗变汉缇ょ敤涓婄殑姣斾緥鏄灏戯紵濡傛灉鍒汉24%鐨勬瘮渚嬭寰楀お浣庯紝鎴戜滑鏄惁鏈夊お澶氶渶瑕佹敼杩涳紵
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鑷充簬鏌愬涓爣鍏徃澶ц皥浠€涔堣鍒╂皯浼楋紝鍛靛懙锛岃鍒╃殑鍓嶆彁涔熷緱鏄嵂鏈夌敤鍚э紵鍦ㄥ晢瑷€鍟嗭紝浣曞繀鎼炶棌鎷欑ず浠佽繖濂楁妸鎴忋€傛湁鏃跺€欙紝璇村緱澶究瀹滐紝鍙嶈€岃浜烘媴蹇冭儗鍚庣殑浠ｄ环鏇撮珮銆?/p>
鍙傝€冭祫鏂?/p>
https://www.npr.org/sections/health-shots/2022/02/01/1075876794/feds-contract-with-pfizer-for-paxlovid-has-some-surprises
https://www.mmm-online.com/home/channel/paxlovid-has-been-free-so-far-next-year-sticker-shock-awaits/
https://www.nejm.org/doi/full/10.1056/NEJMoa2118542
https://www.nejm.org/doi/full/10.1056/NEJMoa2116846
https://icer.org/news-insights/press-releases/icer-provides-update-on-value-based-pricing-of-paxlovid-as-an-outpatient-treatment-for-covid-19/
https://aspe.hhs.gov/sites/default/files/documents/a19600d0dccfee0e9c595730d73fd66d/covid-antivirals-report.pdf
