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鎼哄甫杩欎箞澶氳嚧鍛界梾姣掞紝铦欒潬鎬庝箞灏变笉鐢熺梾锛熴€婄粏鑳炪€
更新时间:2023-02-23

鈻庤嵂鏄庡悍寰峰唴瀹瑰洟闃熺紪杈?/strong>

鏃犺浠庡摢涓搴︽潵鐪嬶紝铦欒潬鍦ㄥ摵涔冲姩鐗╀腑閮芥槸鐙爲涓€甯滅殑涓€鏀€傚畠浠槸鍞竴鑳借嚜涓婚琛岀殑鍝轰钩鍔ㄧ墿锛涘叿鏈夋儕浜虹殑鐗╃澶氭牱鎬э紝姣?涓摵涔冲姩鐗╃墿绉嶄腑灏辨湁涓€涓睘浜庤潤铦狅紱鎷ユ湁鐙壒鐨勫洖澹板畾浣嶇郴缁燂紝鑳藉湪榛戞殫涓惉娓呭懆鍥寸殑涓€鍒囷紱杩樻湁鐫€瓒呴暱瀵垮懡鍜岀嫭鐗圭殑鍏嶇柅鍔涖€?/p>

瀵逛汉绫绘潵璇达紝铦欒潬鐨勫彟涓€椤圭壒娈婁箣澶勪笌鎴戜滑鐨勫仴搴峰瘑鍒囩浉鍏筹細铦欒潬鏄绉嶇梾姣掕繘鍏ヤ汉浣撲箣鍓嶇殑鑷劧瀹夸富锛屼絾闂鏄紝瀹冧滑鎼哄甫浜嗚繖涔堝鑷村懡鐥呮瘨锛屼负浠€涔堣嚜宸卞嵈瀹夌劧鏃犳仚锛?/strong>

鈻?/strong>椹搧鑿婂ご铦狅紙鍥剧墖鏉ユ簮锛欴aniel Whitby锛?/strong>

鐩墠锛屽铦欒潬鐨勭爺绌跺瓨鍦ㄤ竴椤归噸瑕侀殰纰嶏細缂哄皯鍙潬鐨勮潤铦犵粏鑳炴ā鍨嬨€傚彈铦欒潬缁勭粐鏍锋湰闄愬埗锛屽铦欒潬鐨勫疄楠屽鐮旂┒甯稿父閬囧埌鍥伴毦銆?/p>

鐜板湪锛屼竴椤瑰彂琛ㄤ簬銆婄粏鑳炪€嬬殑鐮旂┒鏀瑰彉浜嗚繖涓€灞€闈€傝繖椤圭敱瑗垮灞变紛鍧庡尰瀛﹂櫌鐨勭瀛﹀棰嗗鐨勭爺绌讹紝棣栨鐢熸垚铦欒潬鐨勮瀵兼€у鑳藉共缁嗚優锛坕PSC锛夛紝涓鸿潤铦犵殑缁嗚優鐢熺墿瀛︾爺绌舵彁渚涗簡閲嶈骞冲彴銆?/strong>鍚屾椂锛岀爺绌跺洟闃熷埄鐢ㄨ繖涓€妯″瀷鍙戠幇浜嗚潤铦犲畨鍏ㄦ惡甯︾梾姣掔殑绾跨储锛?strong>铦欒潬涓庣梾姣掔殑鍏崇郴浼间箮姣旈鎯崇殑鏇村姞閿欑患澶嶆潅銆?/strong>

鍦ㄥ彂鑲茶繃绋嬩腑锛屸€滄棤鎵€涓嶈兘鈥濈殑骞茬粏鑳炲垎鍖栨垚鍚勭绫诲瀷鐨勭粏鑳炪€傚湪姝e父鎯呭喌涓嬶紝杩欎釜杩囩▼鏄笉鍙€嗙殑銆?006骞达紝鏃ユ湰绉戝瀹跺北涓几寮ユ暀鎺堟垚鍔熷皢鏃堕挓鈥滃洖鎷ㄢ€濓紝鎻愬嚭浜嗚瀵兼垚鐔熺粏鑳炲洖褰掑鑳藉共缁嗚優鐨勭瓥鐣ワ細Oct4銆丼ox2銆並lf4鍜宑-Myc杩?绉嶁€?strong>灞变腑鍥犲瓙鈥濈殑缁勫悎锛屽彲浠ュ疄鐜扮粏鑳炵殑閲嶇紪绋嬶紝鍥炲埌iPSC闃舵銆?/p>

鍦ㄦ渶鏂扮爺绌朵腑锛岀爺绌跺洟闃熸鏄簲鐢ㄥ北涓洜瀛愭潵澶勭悊椹搧鑿婂ご铦?/strong>锛圧hinolophus ferrumequinum锛夌殑缁嗚優銆備絾浠栦滑鍙戠幇锛岃繖4绉嶅洜瀛愮殑缁勫悎瀵硅潤铦犵粏鑳炲苟涓嶅鏁堛€?/p>

鍦ㄦ帴涓嬫潵鐨勬暟鏈堜腑锛岀爺绌跺洟闃熷皾璇曢噸鏂板鎵捐潤铦犱笓鐢ㄧ殑閲嶇紪绋嬮厤鏂广€傚湪璋冩暣浜?绉嶅北涓洜瀛愮殑姣斾緥锛屽苟娣诲姞Lif锛堢櫧琛€鐥呮姂鍒跺洜瀛愶級銆丼cf锛堝共缁嗚優鍥犲瓙锛夈€丳ka婵€娲诲墏Forskolin鍜孎gf2锛堟垚绾ょ淮缁嗚優鐢熼暱鍥犲瓙2锛夊悗锛?strong>鐮旂┒鍥㈤槦鎴愬姛灏嗛┈閾佽強澶磋潬鐨勬垚绾ょ淮缁嗚優璇卞涓篿PSC銆?/strong>闅忓悗锛屼粬浠娇鐢ㄥ彟涓€绉嶄翰缂樺叧绯昏緝杩滅殑浠h〃鎬ц潤铦犵墿绉?strong>澶ч紶鑰宠潬锛圡yotis myotis锛夐噸澶嶄簡瀹為獙锛屽悓鏍峰彇寰椾簡鎴愬姛銆?/p>

鈻?/strong>璇卞铦欒潬缁嗚優鍥炲埌iPSC闃舵鐨勬祦绋嬶紙鍥剧墖鏉ユ簮锛氬弬鑰冭祫鏂橻1]锛?/strong>

鐢辨锛岀爺绌跺洟闃熷垱寤轰簡閫傜敤浜庤潤铦犵殑iPSC璇卞宸ュ叿銆傝潤铦犲共缁嗚優妯″瀷鐨勫嚭鐜帮紝浣垮緱瀵硅潤铦犵殑缁嗚優鐢熺墿瀛︾爺绌跺皢涓嶅啀鍙楃爺绌舵潗鏂欑殑闄愬埗鈥斺€旇潤铦犲共缁嗚優鍙互鍦ㄥ疄楠屽涓繚瀛橈紝骞舵牴鎹爺绌堕渶瑕佸垎鍖栦负鍚勭缁勭粐銆?/p>

閫氳繃瀵规瘮铦欒潬涓庡叾浠栧摵涔冲姩鐗╃殑iPSC锛岀爺绌跺洟闃熷彂鐜颁簡铦欒潬骞茬粏鑳炵殑鐙湁鐗瑰緛锛?strong>瀹冧滑鐨勭粏鑳炶川涓厖婊′簡鍥婃场锛岃繖鏄湪鍏朵粬鍝轰钩鍔ㄧ墿鐨勫鑳藉共缁嗚優涓湭鏇惧彂鐜扮殑銆?/p>

璁烘枃閫氳浣滆€呬箣涓€Adolfo Garc铆a-Sastre鏁欐巿琛ㄧず锛氣€滆繖椤圭爺绌舵渶浠や汉鎸鐨勪竴椤瑰彂鐜帮紝灏辨槸铦欒潬骞茬粏鑳炰腑鍑虹幇浜嗗惈鏈夌梾姣掔殑鍥婃场锛屼絾杩欏苟涓嶄細濡ㄧ缁嗚優澧炴畺銆佺敓闀跨殑鑳藉姏銆傝繖鎰忓懗鐫€铦欒潬涓庣梾姣掑舰鎴愪簡涓€绉嶅叡鐢熷叧绯伙紝杩欎篃涓鸿潤铦犲繊鍙楃梾姣掔殑鑳藉姏鎻愬嚭涓€绉嶆柊妯″紡銆?/strong>鈥?/p>

鈻茬爺绌剁ず鎰忓浘锛堝浘鐗囨潵婧愶細鍙傝€冭祫鏂橻1]锛?/strong>

璁烘枃鎸囧嚭锛岃繖椤圭爺绌舵敮鎸佷簡涓や釜瑙i噴铦欒潬涓轰粈涔堜笉鎯ф€曠梾姣掔殑鍋囪銆備竴绉嶅彲鑳芥€ф槸锛屽湪铦欒潬鐨勬紨鍖栬繃绋嬩腑锛?strong>鍏跺厛澶╂€у厤鐤郴缁熺粡杩囨敼閫狅紝鎶楃梾姣掑厤鐤€氶亾鍙楀埌浜嗘姂鍒躲€?/strong>鍥犳锛岃潤铦犳紨鍖栧嚭浜嗚兘澶熶笌鐥呮瘨鍏辩敓锛屽苟涓斾笉鍑虹幇鐥囩姸鐨勮兘鍔涖€傚彟涓€绉嶈В閲婂垯鏄潤铦犳紨鍖栧嚭浜嗙粏鑳炵紪绋嬫満鍒讹紝灏卞儚鐥呮瘨鎿嶇旱瀹夸富缁嗚優鐨勮繃绋嬩竴鏍凤紝铦欒潬鐨勮繖绉嶆満鍒朵細鏀寔鐥呮瘨鐨勫鍒朵笌鐢熷瓨銆?/strong>

鐮旂┒鍥㈤槦杩樻敞鎰忓埌锛屼竴浜涚梾姣掞紙灏ゅ叾鏄€嗚浆褰曠梾姣掞級鍙互灏嗛仐浼犵墿璐ㄦ彃鍏ヨ潤铦爄PSC鐨勫熀鍥犵粍骞堕噸鍥炴椿璺冪姸鎬侊紝鐢辨褰㈡垚澶ч噺鍐呮簮鎬х梾姣掑簭鍒?/strong>锛屽苟鐢熸垚澶ч噺铔嬬櫧銆傜爺绌跺洟闃熺寽鎯筹紝铦欒潬骞朵笉浼氭姂鍒惰繖浜涙椿璺冪殑搴忓垪锛屽洜涓哄叾澶嶅埗琛屼负鍙兘鎴愪负鎶靛尽鍏朵粬鐥呮瘨鐨勯槻寰℃満鍒舵垨鈥滅柅鑻椻€濄€?/strong>

鈻茶潤铦爄PSC涓嚭鐜板ぇ閲忔椿璺冪殑鍐呮簮鎬х梾姣掑厓浠?/strong>锛堝浘鐗囨潵婧愶細鍙傝€冭祫鏂橻1]锛?/strong>

鈥滄垜浠殑鐮旂┒琛ㄦ槑锛?strong>铦欒潬婕斿寲鍑轰簡鑳藉繊鍙楀ぇ閲忕梾姣掑簭鍒楃殑鏈哄埗锛屽畠浠笌鐥呮瘨鐨勫叧绯讳篃姣斾互寰€璁や负鐨勬洿鍔犲鏉?/strong>锛屸€濋瀵艰繖椤圭爺绌剁殑Thomas Zwaka鏁欐巿璇达紝鈥滆澶氬浜虹被鑰岃█鑷村懡鐨勭梾姣掞紝鍗磋兘涓庤澶氳潤铦犵墿绉嶅叡瀛樸€傚彲鑳界殑鍘熷洜鏄铦欒潬鍏堝ぉ鎬у厤鐤簲绛旂殑璋冭妭锛屼娇寰楀畠浠垚涓烘棤鐥囩姸銆佽兘蹇嶅彈鐥呮瘨鐨勫涓汇€傗€?/p>

鎺ヤ笅鏉ワ紝鏇村鐮旂┒灏嗗铦欒潬涓庣梾姣掑叡瀛樼殑鍋囪杩涜鎺㈢储銆傚熀浜庤繖椤圭爺绌跺紑鍙戠殑鏂板钩鍙帮紝鏈潵鐨勭爺绌朵笉浠呰兘鎺㈢储铦欒潬鐨勬洿澶氱濂囩壒鎬э紝鎴栬杩樿兘閫氳繃鍩哄洜缂栬緫鏉ユā浠胯潤铦犵殑鏈哄埗锛屾壘鍒伴伩鍏嶇梾姣掓敾鍑荤殑鏂扮瓥鐣ャ€?/strong>杩欎簺甯︾粰浜虹被涓嶅ソ鍥炲繂鐨勫姩鐗╋紝涔熻涔熻兘涓烘敼鍠勪汉绫荤殑鍋ュ悍鍋氬嚭鎰忔兂涓嶅埌鐨勮础鐚€?/p>

鍙傝€冭祫鏂欙細

[1] Thomas P. Zwaka, Bat pluripotent stem cells reveal unusual entanglement between host and viruses, Cell (2023). DOI: 10.1016/j.cell.2023.01.011

[2] First stem cells from a bat species could shed light on virus survival and molecular adaptability. Retrieved Feb. 21st, 2023 from https://www.eurekalert.org/news-releases/979490

[3] How do bats live with so many viruses? New bat stem cells hint at an answer. Retrieved Feb. 21st, 2023 from https://www.science.org/content/article/how-do-bats-live-so-many-viruses-new-bat-stem-cells-hint-answer

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关键词:鎼哄,甫杩,欎箞,澶氳,嚧鍛界,梾姣,掞紝,铦欒,
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