鈻庤嵂鏄庡悍寰峰唴瀹瑰洟闃熺紪杈?/strong>
鍦ㄥ姩鐗╃晫锛岃8榧归紶锛圚eterocephalus glaber锛夊彲浠ヨ鏄笉鎶樹笉鎵g殑鈥滃钁┾€濈墿绉嶃€傚畠浠浉璨屽鐗癸紝鐢变簬缂哄皯姣涘彂鐨勮鐩栵紝瑁搁湶鍦ㄥ鐨勭毊鑲よ瀹冧滑鏋佸叿杈ㄨ瘑搴︺€傚悓鏃讹紝瑁搁脊榧犵殑涓€绯诲垪鐢熺悊鐗瑰緛涔熶护绉戝瀹朵滑鎯婂徆涓嶅凡銆傚畠浠槸鍟娇鍔ㄧ墿涓殑闀垮鏄庢槦锛屽鍛芥槸灏忛紶鐨勫崄鍑犲€嶏紱瀹冧滑鍑犱箮涓嶅緱鐧岀棁锛屽苟涓旂湅涓婂幓浼间箮涓嶄細琛拌€佲€︹€?/p>
浠婂ぉ锛屻€婅嚜鐒堵烽€氳銆嬫潅蹇楃殑涓€椤圭爺绌舵彮寮€浜嗚8榧归紶鐨勫張涓€涓皽鍥細瀹冧滑鐨勭敓鑲茶兘鍔涗负浠€涔堣兘鎸佺画缁堢敓锛?/strong>
鎴戜滑鍜屽叾浠栧姩鐗╁姩鐗╀竴鏍凤紝鐢熻偛鑳藉姏浼氶殢鐫€琛拌€佽繃绋嬭€屼笅闄嶃€備絾瑁搁脊榧犵殑鐢熻偛鑳藉姏鍗磋疮绌夸簡瀹冧滑闀垮鐨勪竴鐢熴€?/p>
鈥滃鎴戞潵璇达紝瑁搁脊榧犳渶浠や汉鎯婅鐨勪竴鐐规槸锛屽畠浠粠涓嶄細鍋滄鐢熻偛鈥斺€旈殢鐫€骞撮緞鐨勫闀匡紝瀹冧滑鐨勭敓鑲茶兘鍔涗笉浼氫笅闄嶃€傛垜浠兂浜嗚В锛屽畠浠槸濡備綍鍋氬埌杩欎竴鐐圭殑銆傗€濊鏂囩涓€浣滆€咃紝鍖瑰吂鍫″ぇ瀛﹀姪鐞嗘暀鎺圡iguel Brie帽o-Enr铆quez璇淬€?/p>
棣栧厛瑕佺煡閬撶殑鏄紝缁濆ぇ澶氭暟鍝轰钩鍔ㄧ墿鐨勭敓鑲茶兘鍔涗负浠€涔堜細闅忓勾榫勫闀胯€屼笅闄嶃€傞€氳繃瀛愬鍐呯殑鍗靛瓙鍙戠敓杩囩▼锛岄泴鎬у摵涔冲姩鐗╁湪鍑虹敓鏃舵惡甯︿簡鏈夐檺鏁伴噺鐨勫嵉缁嗚優銆傞殢鐫€鏃堕棿鎺ㄧЩ锛屽叾涓竴閮ㄥ垎鍗电粏鑳炲湪鎺掑嵉鏈熸帓鍑猴紝鑰屾洿澶氱殑鍒欐槸鐩存帴姝讳骸锛屽洜姝?strong>鍗电粏鑳炵殑渚涘簲閫愭笎鑰楀敖锛屽鑷寸敓鑲茶兘鍔涗笅闄嶃€?/strong>
鈻茶8榧归紶锛堝浘鐗囨潵婧愶細UPMC锛?/i>Brie帽o-Enr铆quez鏁欐巿鎺ㄦ祴锛岃8榧归紶淇濇寔鐢熻偛鑳藉姏鐨勬綔鍦ㄧ瓥鐣ユ湁3绉嶏細鈥?strong>瀹冧滑鍑虹敓鏃跺氨鎷ユ湁澶ч噺鍗电粏鑳烇紝鎴栬€呬笉浼氭湁澶ч噺鍗电粏鑳炴浜★紝鍙堟垨鑰呮槸瀹冧滑鍦ㄥ嚭鐢熶箣鍚庝粛鑳芥寔缁骇鐢熷嵉缁嗚優銆?/strong>鎴戞渶鍠滄鐨勫亣璇存槸锛屽畠浠娇鐢ㄤ簡杩?绉嶇瓥鐣ョ粍鎴愮殑鈥橀浮灏鹃厭鈥欍€傗€?/p>
鍦ㄨ繖椤圭爺绌朵腑锛屼綔鑰呮灉鐒朵负杩?涓繃绋嬫壘鍒颁簡鍚勮嚜鐨勮瘉鎹€?/p>
鐮旂┒鏄剧ず锛屼笌灏忛紶鐩告瘮锛?strong>闆屾€ц8榧归紶鎷ユ湁鐨勫嵉缁嗚優鏁伴噺瑕佸寰楀锛屽苟涓旇繖浜涚粏鑳炵殑姝讳骸鐜囦篃鏇翠綆銆?/strong>渚嬪鍦ㄥ嚭鐢?澶╂椂锛岄泴鎬ц8榧归紶骞冲潎鎼哄甫浜?50涓囨灇鍗电粏鑳烇紝鏄悓榫勫皬榧犵殑杩戠櫨鍊嶃€?/p>
鏇翠护浜烘剰澶栫殑鏄紝鐮旂┒鍥㈤槦鍦ㄥ嚭鐢熷悗鐨勯泴鎬ц8榧归紶浣撳唴涔熷彂鐜颁簡鍗靛瓙鍙戠敓鐨勮瘉鎹€傚嵉瀛愬墠浣撶粏鑳炲湪3涓湀澶х殑瑁搁脊榧犱綋鍐呭垎瑁傜姸鎬佹椿璺冿紝骞朵笖鍦?0宀佸ぇ鐨勮8榧归紶涓篃鍙戠幇浜嗚繖绫荤粏鑳烇紝杩欐剰鍛崇潃鍗靛瓙鍙戠敓杩囩▼鍙兘璐┛浜嗗畠浠殑涓€鐢熴€?/strong>
鈥滆繖涓€鍙戠幇闈炲悓瀵诲父锛屸€濋瀵艰繖椤圭爺绌剁殑搴峰灏斿ぇ瀛ed Place鏁欐巿璇达紝鈥?strong>杩欓」鐮旂┒鍚戝瓨鍦ㄨ繎70骞翠箣涔呯殑鏁欐潯鍙戣捣浜嗘寫鎴?/strong>锛屽湪杩囧幓鐨勭悊璁轰腑锛岄泴鎬у摵涔冲姩鐗╁湪鍑虹敓鍚庝笉涔呭彧鎷ユ湁鏈夐檺鐨勫嵉缁嗚優锛岃€屾棤娉曞啀鍚戝嵉宸㈠偍搴撴坊鍔犳柊鐨勫嵉缁嗚優銆傗€?/p>
鈻茶8榧归紶鐨勫嵉宸㈠惈鏈夊法澶х殑鍗电粏鑳炲偍搴擄紙鍥剧墖鏉ユ簮锛氬弬鑰冭祫鏂橻1]锛?/i>鎸佺画鐨勫嵉瀛愬彂鐢熻繃绋嬩篃瑙i噴浜嗚8榧归紶鐨勭ぞ浼氬舰鎬併€備綔涓轰竴绉嶇兢灞呭姩鐗╋紝瑁搁脊榧犱笌铚滆渹銆佽殏铓佷竴鏍凤紝鍙湁缁熸不鍦颁綅鐨勯泴鎬р€滃コ鐜嬧€濇墠鑳界箒娈栵紱浣嗕笌铚滆渹銆佽殏铓佷笉鍚岀殑鏄紝杩欎簺瑁搁脊榧犲苟涓嶆槸澶╃敓鐨勨€滃コ鐜嬧€濄€傚綋鈥滃コ鐜嬧€濇浜℃垨琚刀鍑鸿繖涓兢浣撳悗锛屽叾鍘熸湰鐨勪粠灞為泴鎬т細绔炰簤銆佸彇浠e師鏉ョ殑鈥滃コ鐜嬧€濈殑浣嶇疆锛岃繖鏃跺叾鐢熸畺鑳藉姏涔熷緱鍒颁簡婵€娲汇€備篃灏辨槸璇达紝浠讳綍闆屾€ч兘鏈夊彲鑳芥垚涓衡€滃コ鐜嬧€濄€?/p>
鎺ヤ笅鏉ワ紝鐮旂┒鍥㈤槦灏嗕竴鍙?宀佺殑闆屾€т粠瑁搁脊榧犵ぞ缇や腑鍙栧嚭锛屾縺娲诲叾鐢熻偛鑳藉姏銆備粬浠彂鐜帮紝杩欎簺闆屾€у皬榧犲師鏈氨鏈夊嵉瀛愬墠浣撶粏鑳烇紝浣嗗彧鏈夊湪鎴愪负濂崇帇鏃舵墠寮€濮嬪垎瑁傘€?/strong>
鈥滆繖涓€鐐瑰緢閲嶈锛屽鏋滄垜浠兘澶熷紕娓呮瑁搁脊榧犲浣曞仛鍒拌繖涓€鐐癸紝灏辨湁甯屾湜寮€鍙戝嚭鏂扮殑鑽墿闈剁偣鎴栨妧鏈潵缁存寔鍋ュ悍锛屸€滲rie帽o-Enr铆quez鏁欐巿璇达紝鈥滃嵆浣夸汉绫诲鍛芥洿闀匡紝浣嗘洿骞存湡浠嶇劧鍙戠敓鍦ㄤ笌瑁搁脊榧犵浉鍚岀殑骞撮緞銆傛垜浠笇鏈涘埄鐢ㄦ墍瀛︾殑涓滆タ鍦ㄦ湭鏉ヤ繚鎶ゅ嵉宸㈠姛鑳斤紝骞跺欢闀跨敓鑲茶兘鍔涖€傗€?/p>
鍙傝€冭祫鏂欙細
[1] Soerens, A.G., K眉nzli, M., Quarnstrom, C.F. et al. Functional T cells are capable of supernumerary cell pision and longevity. Nature (2023). https://doi.org/10.1038/s41586-022-05626-9
[2] Immune Cells Can Avoid Aging to Produce Progeny 30,000x the Earth鈥檚 Volume. Retrieved Feb. 20, 2023 from https://www.nad.com/news/immune-cells-can-avoid-aging-to-produce-progeny-30000x-the-earths-volume
[3] The Case of the Incredibly Long-Lived Mouse Cells. Retrieved Feb. 20, 2023 from https://www.wired.com/story/the-case-of-the-incredibly-long-lived-mouse-cells/