12.29
鐭ヨ瘑鍒嗗瓙
The Intellectual
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璐ｇ紪 | 寰愬崜鍚?/strong>
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浣滀负鍏ㄤ笘鐣屾渶鍙楀叧娉ㄧ殑鏂板啝鍙ｆ湇鎶楃梾姣掕嵂锛岃緣鐟炵殑Paxlovid杩戞湡鎴愪簡鐑悳涓撲笟鎴枫€傚浗鍐呭瀹跺獟浣撴姤閬擄紝浣滀负澶勬柟鑽殑Paxlovid鐨勨€滈粦甯傗€濅环宸茬粡琚倰鍒颁竾鍏冧互涓娿€?/p>
鎹€婄煡璇嗗垎瀛愩€嬩簡瑙ｏ紝澶氬涓夌敳鍖婚櫌鐨凱axlovid渚涘簲鏋佸叾鏈夐檺锛屼复搴婁竴绾跨殑楠ㄥ共鈥斺€斿壇涓讳换鍖诲笀鍜屼富娌诲尰甯堥兘娌℃湁寮€鑽殑鏉冮檺銆?/p>
涓庢鍚屾椂锛屽寳浜紶鍑鸿繎鏈熷皢Paxlovid閰嶉€佽嚦鍚勪釜绀惧尯鍗敓鏈嶅姟涓績锛涙洿澶氱殑浜猴紝姣忓ぉ瀹氭椂瀹堝湪鍚勫ぇ浜掕仈缃戝钩鍙版嫾鈥滄墜閫熲€濇姠鑽€?/p>
浣滀负涓€娆惧拰澶氱鑽墿鏈夊啿绐佷綔鐢ㄧ殑澶勬柟鑽紝涓€椤规瀬涓洪噸瑕佺殑鎶楃柅鐗╄祫锛屽凡缁忔垚涓哄叏姘戝搫鎶㈢殑鐨勫璞°€?/p>
杩欑绉嶇幇璞★紝璁╂垜浠笉绂佸彂闂細鏂板啝鍙ｆ湇鑽埌搴曡濡備綍鍒嗛厤锛熷湪璇ヨ嵂浣跨敤鏈€骞挎硾鐨勭編鍥斤紝鏈夊摢浜涚粡楠屽彲渚涘€熼壌锛?/p>
1
Paxlovid璇ョ粰璋佺敤锛?/p>
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浠庤嵂鐗╂満鐞嗙湅锛孭axlovid鏄€氳繃鎶戝埗鏂板啝鐥呮瘨鐨勫鍒舵潵闄嶄綆鐥呮瘨杞介噺銆傚弬鑰冩柊鍐犵殑鑷寸梾鏈哄埗锛岀梾姣掑鍒堕珮宄版槸鍦ㄦ劅鏌撴棭鏈燂紝澶ч噺鐨勭梾姣掍細杩涗竴姝ュ鑷寸粍缁囨崯浼ょ敋鑷宠瀵艰繃婵€鐨勫厤鐤弽搴旓紝鏈€缁堝紩鍙戦噸鐥囥€?/p>
浜岃€呭搴斿湪涓€璧凤紝涓嶉毦鍙戠幇Paxlovid蹇呴』瑕佺敤鍦ㄦ劅鏌撴棭鏈燂紝骞朵笖鏄皻鏈彂灞曞埌閲嶇棁鐨勬椂鏈熴€傚彧鏈夊湪鎰熸煋鏃╂湡锛岀梾姣掍粛澶勪簬澶ч噺澶嶅埗闃舵锛屾姂鍒剁梾姣掑鍒舵墠鏈夋剰涔夈€傝浆閲嶇棁涔嬪悗锛屾偅鑰呯殑鑷寸梾鏈虹悊涓嶅啀鏄梾姣掑鍒剁殑闂锛屾秹鍙婂埌缁勭粐鎹熶机浠ュ強寮傚寲鐨勫厤鐤弽搴旓紝鍐嶆姂鍒剁梾姣掑鍒舵剰涔夋湁闄愩€?/p>
涓村簥璇曢獙涓庣湡瀹炰笘鐣岃窡韪篃楠岃瘉浜嗕笂杩癙axlovid鑽墿鏈虹悊鐨勭壒寰併€侾axlovid鏈€涓洪噸瑕佺殑鏈夋晥鎬ц瘉鎹彲浠ュ弬鑰冧袱椤圭爺绌讹紝涓€涓槸涓夋湡涓村簥璇曢獙EPIC-HR锛屽彟涓€涓槸浠ヨ壊鍒楀ゥ瀵嗗厠鎴庢椂鏈熺殑鐪熷疄涓栫晫鏁版嵁銆?/p>
鍦ㄥ痉灏斿娴佽鏃舵湡杩涜鐨勪笁鏈熶复搴婅瘯楠孍PIC-HR锛屾槸鍦ㄦ湭鎺ョ鏂板啝鐤嫍涓旀湁鑷冲皯涓€涓柊鍐犻噸鐥囬闄╁洜绱犵殑鎰熸煋鑰呬腑杩涜锛屽湪鎰熸煋鑰呭嚭鐜扮棁鐘舵垨纭瘖5澶╁唴浣跨敤Paxlovid锛堝皻涓嶆槸閲嶇棁锛夛紝鍙戠幇闄嶄綆浣忛櫌鎴栨浜￠闄?8.9%[1]銆?/p>
鏄剧劧瀵逛簬閲嶇棁椋庨櫓杈冮珮鐨勪汉缇わ紝鍦ㄦ劅鏌撴棭鏈熶娇鐢≒axlovid澶у箙闄嶄綆浜嗛噸鐥囦笌姝讳骸鐨勯闄┿€備絾EPIC-HR鏈変袱涓棶棰橈紝涓€鏄瘯楠岃繘琛屾椂鏄嚧鐥呮€ц緝寮虹殑寰峰皵濉旓紝铏界劧Paxlovid鐨勪綔鐢ㄦ満鐞嗕笌鍗曞厠闅嗘姉浣撲互鍙婄柅鑻椾笉鍚岋紝涓嶅彈濂ュ瘑鍏嬫垘绐佸彉褰卞搷锛屼絾濂ュ瘑鍏嬫垘鑷寸梾鎬ф洿寮憋紝浠嶄細甯︽潵璇ヨ嵂鐨勯檷浣庨噸鐥囦綔鐢ㄦ槸鍚﹁繕鏄捐憲鐨勯棶棰樸€備簩鏄疎PIC-HR鍧囦负鏈帴绉嶇柅鑻楃殑浜猴紝闅忕潃鍏ㄧ悆鐤嫍鎺ョ鐜囨彁鍗囷紝鍦ㄦ帴绉嶅畬鐤嫍锛岄噸鐥囬闄╀笅闄嶄箣鍚庯紝Paxlovid鐨勪綔鐢ㄨ繕鑳藉惁浣撶幇锛屼篃鏄竴涓棶棰樸€?/p>
鍥炵瓟杩欎袱涓棶棰橈紝鎴戜滑鍙互鍙傝€冧互鑹擦垪鍦ㄥゥ瀵嗗厠鎴庢毚鍙戞椂鐨勪竴椤圭湡瀹炰笘鐣岀爺绌讹紝璇ョ爺绌跺彂鐜帮紝鍦ㄤ互鑹擦垪杩欐牱涓€涓柅鑻楁帴绉嶇巼闈炲父楂樼殑鍥藉锛?022骞村垵濂ュ瘑鍏嬫垘BA.1鏆村彂鏃讹紝65宀佷互涓婃劅鏌撹€咃紝浣跨敤Paxlovid锛屼綇闄㈢巼鏄?4.7渚嬫瘡鍗佷竾浜哄ぉ锛屾湭浣跨敤Paxlovid鐨勶紝浣忛櫌鐜囧垯鏈?8.9渚嬫瘡鍗佷竾浜哄ぉ锛屼絾40-64宀佷汉缇わ紝鐢ㄤ笉鐢≒axlovid锛屼綇闄㈤闄╂病鏈夊尯鍒玔2]銆?/p>
鍙锛屽嵆渚挎槸鎺ョ瀹岀柅鑻楋紝濡傛灉鏄珮鍗变汉缇わ紙濡傞珮榫勶級锛孭axlovid杩樻槸鑳介檷浣庡ゥ瀵嗗厠鎴庣殑浣忛櫌椋庨櫓銆傚彲鏄湪闈為珮鍗变汉缇ら噷锛岃鑽殑浣滅敤灏变笉鏄庢樉浜嗐€?/p>
缁煎悎澶氶」璇佹嵁锛屾垜浠彲浠ユ槑纭湴鍙戠幇锛孭axlovid鐨勬湁鏁堟€ф槸閽堝灏氭湭鍙戝睍涓洪噸鐥囩殑楂樺嵄浜虹兢锛屽湪鏂板啝鎰熸煋鏃╂湡浣跨敤鍙互闄嶄綆浠栵紙濂癸級浠繘灞曚负閲嶇棁鐢氳嚦姝讳骸鐨勯闄┿€?/p>
鑰屽浗鍐呬竴绐濊渹铚傛嫢鑰屼笂鎶㈣嵂鐨勶紝寰堝閮芥槸杩樻湭鎰熸煋鎴栨牴鏈笉鏄珮鍗变汉缇わ紝鎯虫柟璁炬硶涔拌嵂鏄惁鏈夋剰涔夛紵娌荤枟瀹炶返涓紝鐢变簬渚涚粰鏈夐檺锛孭axlovid寰€寰€鏄珮鍗变汉缇ゅ彂鐥呭嚑鏃ョ棁鐘舵湭濂借浆鐢氳嚦鎭跺寲鍐嶅紑濮嬬敤鑽紝鏄惁鑳借鑽墿鍙戞尌鍑烘渶澶ф晥鏋滐紵杩欎簺閮芥槸瀛樼枒鐨勩€?/p>
闄や簡鏈夋晥鎬т箣澶栵紝鍚堢悊浣跨敤Paxlovid鏇翠笉鑳借劚绂昏嵂鐗╁畨鍏ㄦ€х殑鑼冪暣銆侾axlovid鏈変袱涓垚鍒嗭紝鎶戝埗鏂板啝鐥呮瘨澶嶅埗鐨刵irmatrelvir鍜岀淮鎸乶irmatrelvir娴撳害鐨剅itonavir銆傚鏋滀粠涓村簥璇曢獙鐨勬暟鎹潵鐪嬶紝涓嶈壇浜嬩欢鍙戠敓鐜囧湪鐢ㄨ嵂缁勪笌瀹夋叞鍓傜粍绫讳技锛屾棤娉曡€愬彈鑽墿鑰屽仠鑽殑浜轰粎鏈?.1%锛岃鏄嶱axlovid鐨勫畨鍏ㄦ€у苟涓嶅樊銆傚彲鏄繖鏄湪鏍规嵁鑽墿瀹夊叏鎬х壒寰佹帓闄ゆ帀涓嶉€傜敤鐨勪汉缇ゅ悗鍙栧緱鐨勭粨鏋滐紝鍦ㄥ疄璺典腑涓嶈兘蹇界暐鑲捐剰鍔熻兘鎴栬倽鑴忓姛鑳戒弗閲嶅彈鎹熶笉鑳戒娇鐢≒axlovid鐨勪汉銆傝€屼笖ritonavir瀛樺湪杈冨鐨勮嵂鐗╁啿绐侀棶棰橈紝闇€瑕侀壌鍒摢浜涜嵂鐗╁彲浠ュ叡鍚屼娇鐢紝鍝簺涓嶈銆?/p>
鍥藉唴涓€浜涚綉缁滃钩鍙板敭鑽互鍙婄ぞ鍖哄尰闄㈠煿璁敤鑽紝杩欎簺閫斿緞鑳藉惁璇嗗埆涓嶉€傚悎鐢ㄨ嵂鐨勪汉缇わ紝鎴栬€呭鐞嗗ソ涓庡叾瀹冭嵂鐗╁叡鐢ㄦ椂鐨勮嵂鐗╁啿绐侀棶棰橈紵
涓€浜涙湁鍐茬獊鐨勮嵂闇€瑕佸噺閲忥紝鍙︿竴浜涢渶瑕佸仠鑽紝浣曟椂鎭㈠鑽墿浣跨敤涔熼渶瑕佽€冭檻Paxlovid浣曟椂鑳藉湪浣撳唴浠ｈ阿瀹屻€傜綉缁滃钩鍙般€佺ぞ鍖哄尰鐤楀伐浣滆€呮槸鍚﹀叿澶囪繖绉嶇浉瀵瑰鏉傜殑鍖诲銆佽嵂瀛﹀垽鏂兘鍔涳紵杩欐槸鎴戜滑淇濋殰瀹為檯鑽墿浣跨敤瀹夊叏鏃跺繀椤绘潈琛＄殑銆傝€岀綉缁滄捣澶栦唬璐€滀豢鍒惰嵂鈥濇洿鏄粫寮€浜嗗熀鏈殑鑽搧鐢熶骇璐ㄩ噺鐩戠锛屽瓨鍦ㄥ法澶х殑瀹夊叏闅愭偅闂銆?/p>
2
paxlovid鏄暣浣撻槻鐤殑涓€閮ㄥ垎
闈㈠鍥藉唴鐩墠鏁翠綋渚涘簲杩滀笉瓒充互搴斿澶ч噺鎰熸煋鐨勭柅鎯呯幇瀹烇紝璁╂皯浼楀叏缃戞悳绱㈠浣曡喘涔癙axlovid鏄剧劧鍙細鍔╅暱鑽墿鎸ゅ厬锛岃€屾棤鍔╀簬鏈夋晥鍒嗛厤鑽墿銆?/p>
閭ｄ箞搴旇濡備綍瀹夋帓浼樺厛椤哄簭锛熸€庢牱璁╂劅鏌撹€呮洿鏂逛究鍦拌幏寰楄嵂鐗╋紝鍙堜繚闅滃畨鍏ㄧ敤鑽紵鎴戜滑鍙互鐪嬬湅缇庡浗鍦ㄤ娇鐢ㄣ€佸垎閰峆axlovid鏃剁殑缁忛獙銆?/p>
瑕佺湡姝ｇ敤濂絇axlovid绛夋柊鍐犳姉鐥呮瘨鑽墿锛屼竴涓ぇ鍓嶆彁鏄皢鍏剁撼鍏ユ暣浣撻槻鐤瓥鐣ョ殑涓€閮ㄥ垎銆傚鏋滃幓鍚編鍥借礋璐ｆ柊鍐犻槻鐤殑瀹樺憳銆佷笓瀹朵滑璋堝強Paxlovid鐨勪娇鐢紝鏈€甯哥敤鐨勬弿杩版槸鈥滀竴涓噸瑕佺殑宸ュ叿鈥濇垨鏄€滄墍鏈夐槻鐤伐鍏烽噷闈炲父閲嶈鐨勪竴涓€濄€備篃灏辨槸璇达紝Paxlovid鏄編鍥芥暣浣撶殑闃茬柅瑙勫垝鐨勪竴閮ㄥ垎銆?/p>
Paxlovid鑾峰緱FDA鐨勭揣鎬ヤ娇鐢ㄦ巿鏉冩槸鍦?021骞?2鏈圼3]銆傚綋鏃舵鍊煎ゥ瀵嗗厠鎴嶣A.1鍦ㄥ叏鐞冨紩璧锋劅鏌撻珮宄帮紝瀵艰嚧鏂板啝浣忛櫌銆佹浜′汉鏁版縺澧炪€傝€屽ゥ瀵嗗厠鎴庣殑鍏嶇柅閫冮€哥壒寰佹剰鍛崇潃浠ュ線鏂板啝鏃╂湡娌荤枟鐨勪富鍔涘崟鍏嬮殕鎶椾綋涓嶅皯澶卞幓浜嗕綔鐢ㄣ€?/p>
浠庝竴寮€濮嬶紝Paxlovid鍦ㄦ缇庨槻鐤綋绯讳腑鐨勫畾浣嶅氨鏄埄鐢ㄥ叾鍙ｆ湇鑽殑渚挎嵎鎬э紝闄嶄綆閲嶇棁椋庨櫓杩戜節鎴愮殑楂樻晥鎬э紝鍑忓皯鏂板啝浣忛櫌浜烘暟锛岄檷浣庣柅鎯呭鍖荤枟绯荤粺涔冭嚦绀句細鐨勫啿鍑汇€傝繖涓€瀹氫綅鏄笌鐤嫍浠ュ強鍏跺畠鏂板啝娌荤枟鑽墿浜掕ˉ鐨勩€?/p>
鏂板啝鐤嫍鐨勬帴绉嶅彲浠ュぇ骞呴檷浣庢柊鍐犻噸鐥囬闄┿€傚彲鏄湪涓€浜涢珮鍗变汉缇や腑濡傞珮榫勮€佸勾浜猴紝鎺ョ澶氶拡鏂板啝鐤嫍鍚庣梾姝荤巼浠嶆樉钁楅珮浜庡勾杞讳汉锛屽彟澶栧厤鐤姂鍒朵汉缇ゅ彲鑳芥帴绉嶇柅鑻楃殑鏁堟灉涔熷急浜庢櫘閫氫汉缇わ紝鍥犳Paxlovid鍙互杩涗竴姝ラ檷浣庤繖浜涢珮鍗变汉缇ょ殑閲嶇棁椋庨櫓锛岃浠栵紙濂癸級浠闈㈠鐨勫疄闄呮柊鍐犻闄╀笌鏅€氬仴搴蜂汉鎺ヨ繎銆?/p>
Paxlovid涓婂競涔嬪悗骞舵病鏈夊彇浠ｇ柅鑻楁帴绉嶏紝娆х編浠嶇劧鍦ㄥぇ鍔涙帹杩涢珮鏁堢柅鑻楃殑浣跨敤锛屽寘鎷浠婃洿鏂板埌鍖呭惈濂ュ瘑鍏嬫垘鐗堟湰鐨勪簩浠穖RNA鐤嫍銆傚悓鏃讹紝Paxlovid鐢变簬鍓嶈堪鎻愬埌鐨勮嵂鐗╁啿绐侀棶棰橈紝鏈変簺鎰熸煋鑰呮棤娉曚娇鐢紝鍙﹀涓や釜鎶楃梾姣掕嵂鐗╅粯鍏嬪彛鏈嶈嵂molnupiravir鍜岄潤鑴夋敞灏勭殑鐟炲痉瑗块煢鍦ㄦ柊鍐犳不鐤椾笂浠嶇劧璧风潃閲嶈浣滅敤銆?/p>
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3
缇庡浗鍒嗛厤Paxlovid鐨勬紨鍙?/strong>
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鍦?022骞村垵锛孭axlovid鐨勪緵搴旈噺闈炲父鏈夐檺锛屽2022骞翠竴瀛ｅ害鍏ㄧ悆Paxlovid浜ч噺浼拌浠呬负6-7鐧句竾涓枟绋媅5]銆傞潰瀵瑰ぇ閲忓ゥ瀵嗗厠鎴庢劅鏌撹€咃紝NIH涔熷畾鍑轰簡璇﹀敖鐨勬劅鏌撹€呬娇鐢ㄤ紭鍏堥『浣嶏紝淇濊瘉璁╅噸鐥囬闄╂渶楂樼殑浜鸿兘鏈€鍏堢敤涓婅嵂锛屼篃璁╄嵂鐗╁彂鎸ユ渶澶т綔鐢╗6]锛?/p>
鍥韭?/strong>NIH鐨刾axlovid渚涘簲浼樺厛椤哄簭
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鍊煎緱娉ㄦ剰鐨勬槸锛屽湪鑽搧渚涘簲鐨勯『搴忎腑锛孨IH鐨勬帹鑽愭槸瀹屽叏渚濇嵁閲嶇棁椋庨櫓鐨勯珮浣庯紝鑰岄潪鎰熸煋鏃剁梾鎯呬弗閲嶇▼搴︺€?/p>
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绗簩涓斂绛栦笌绗竴鏉＄浉鍏筹紝灏辨槸鎺ㄥ箍妫€娴嬪埌娌荤枟鐨勪竴鏉￠緳鏈嶅姟锛坱est to treat锛塠7]銆傜編鍥芥湁寰堝绀惧尯鑽埧锛屽眳姘戝钩鏃跺彇澶勬柟鑽瓑寰€寰€涔熷湪杩欎簺绀惧尯鑽埧銆傞櫎姝や箣澶栵紝涓€浜涜嵂鎴胯繕鍏艰亴绀惧尯鍐呯殑椋熷搧搴椼€佹潅璐у簵銆傝€屽緢澶氳嵂鎴垮氨鏈夎嵂鍓傚笀褰撳€笺€傚洜姝わ紝缇庡浗鏀垮簻涓庡緢澶氳嵂鎴垮悎浣滐紝璁╁眳姘戝彲浠ョ洿鎺ュ湪鑽埧鍋氭娴嬨€佸彇鑽€備箣鍚庤繘涓€姝ユ墿灞曞埌鍙互绾夸笂涓庡尰鍔′汉鍛樿仈绯伙紝纭鏄惁鍙互浣跨敤Paxlovid锛屽啀鍒拌嵂鎴垮彇鑽€?/p>
娣卞叆绀惧尯鐨勬娴嬪埌娌荤枟鐨勪竴鏉￠緳锛屽湪鑽墿渚涘簲閲忓厖瓒崇殑鍓嶆彁涓嬶紝鍙互璁╂洿澶氫笉澶効鎰忓幓鍖婚櫌灏卞尰鐨勬劅鏌撹€呰幏寰椾娇鐢≒axlovid鐨勬満浼氥€備笉杩囪娉ㄦ剰Paxlovid浠嶇劧鏄鏂硅嵂锛岃櫧鐒跺鏂规潈鎵╁睍鍒拌嵂鍓傚笀锛屼絾NIH绛変笓涓氭満鏋勪粛鐒舵槸鎻愪緵浜嗗ぇ閲忕殑鐩稿叧瀹夊叏鐢ㄨ嵂鍩硅锛岄槻姝㈣嵂鐗╃殑婊ョ敤涓庝笉瀹夊叏浣跨敤銆?/p>
4
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绗竴锛屽湪閮ㄥ垎鍥藉鍜屽湴鍖猴紝Paxlovid绛夋柊鍐犳不鐤楄嵂鐗╅兘鏄斂搴滈泦涓噰璐紝鍐嶆寜瀹為檯闇€姹傚垎閰嶃€傚湪鐤儏鑳屾櫙涓嬶紝鍙湁杩欑鏂瑰紡鎵嶅彲浠ュ皢鑽墿鍒嗛厤缁欓噸鐥囬闄╂洿楂樼殑浜猴紝涔熷氨鏄渶闇€瑕佺殑鎰熸煋鑰呰韩涓娿€傚悓鏃讹紝鍦ㄤ緵搴旈噺涓婂悜姘戜紬鍏紑锛屼篃鍙互璁╁叕姘戝鏀垮簻鐨勯槻鐤洿鏈変俊蹇冦€?/p>
鏃犺鏄獟浣撹繕鏄叕浼楋紝瀵圭柅鎯呯殑鍏虫敞浼氶毦鍏嶄細甯﹀叆鍋忓樊銆傛瘮濡傛垜浠細鏇村鏄撶湅鍒板ぇ鍩庡競鐨勭柅鎯咃紝鍙槸鏂板啝鐥呮瘨鐨勪紶鎾苟涓嶄负澶存潯鏂伴椈鐨勬暟閲忔墍鍔ㄣ€傚亸杩滃湴鍖轰竴鏍峰彲鑳介亣鍒板ぇ閲忔劅鏌擄紝涓€鏍蜂細闇€瑕佹姉鐥呮瘨鑽潵搴斿鐤儏銆傞泦涓絾閫忔槑鐨勫垎閰嶆柟寮忥紝涔熻兘璁╀笉鍚屽湴鍖洪棿鑾峰緱鑽墿鐨勬満浼氭洿骞崇瓑銆備緥濡傦紝缇庡浗鐨勫崼鐢熼儴浼氭瘡鍛ㄦ洿鏂板寘鎷琍axlovid鍦ㄥ唴鍚勭鏂板啝娌荤枟鑽墿鐨勫埌璐с€佸垎鍙戞儏鍐碉紝璁╁叕浼椾簡瑙ｆ瘡涓湴鍖洪兘鏈夊叕骞充笖鍏呭垎鐨勬満浼氳幏寰楅槻鐤墿璧刐8]銆?/p>
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绗簩锛孭axlovid鐨勫叿浣撲娇鐢ㄩ渶瑕佸尰瀛︿笓涓氭妸鍏炽€侾axlovid浣滀负澶勬柟鑽€屼笉鏄潪澶勬柟鑽槸鏈夊師鍥犵殑锛屾綔鍦ㄧ殑浼楀鑽墿鍐茬獊锛屾劅鏌撹€呭湪鐢ㄨ嵂鍓嶉渶瑕佷笓涓氱殑鍖荤敓銆佽嵂鍓傚笀鍒ゆ柇濡備綍瀹夊叏鐢ㄨ嵂銆傞潰瀵瑰ぇ閲忔劅鏌擄紝涓浗闇€瑕佹帹骞縋axlovid鐨勪娇鐢紝浣嗚繖绉嶆帹骞垮繀椤绘槸瀹夊叏鐨勬帹骞裤€傛垜浠渶瑕佸強鏃跺鍥藉唴鍖诲姟浜哄憳鍋歅axlovid鐨勭瀛﹀煿璁紝杩欐墠鏄湭鏉ュ畨鍏ㄧ敤鑽殑鍩虹煶銆?/p>
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鏈€鍚庯紝鎴戜滑闇€瑕佷紶閫掍笓涓氥€佺瀛︾殑闃茬柅淇℃伅鈥斺€斿寘鎷湡瀹炵殑Paxlovid璧勮銆備緥濡傜綉涓婂瓨鍦ㄥぇ閲忚喘涔癙axlovid浠垮埗鑽殑淇℃伅銆傚彲鏄疨axlovid鐨勪豢鍒惰嵂璁稿彲鏄拡瀵逛綆鏀跺叆鍥藉鐨勶紝涓浗骞朵笉鍦ㄥ叾涓€傝繖鎰忓懗鐫€鍖呮嫭涓浗鍥藉唴鑾峰緱Paxlovid浠垮埗璁稿彲鐨勮嵂浼佸湪鍐咃紝鎵€鏈変豢鍒剁増鏈殑paxloivd锛屽湪涓浗鍑哄敭鍧囨槸闈炴硶锛屾病鏈変换浣曠洃绠℃満鏋勭殑鎶婂叧锛屼篃鏃犳硶淇濊瘉鍏跺熀鏈殑鐢熶骇璐ㄩ噺銆佸畨鍏ㄦ€с€傚厑璁歌繖浜涒€滀豢鍒惰嵂鈥濆湪浜掕仈缃戜笂娉涙互锛岀粰涓嶆硶涔嬪緬鐣欎笅浜嗙墴鍙栨毚鍒╃殑鏈轰細锛屼篃缁欐皯浼楀甫鏉ヤ簡宸ㄥぇ鐨勫仴搴烽殣鎮ｃ€?/p>
鍙堟瘮濡傜敱浜庝緵搴旈噺鏈夐檺锛屼笉灏戝尰闄娇鐢≒axlovid闄愬埗鍦ㄤ簡杩炵画鍑犲ぉ鍙戠儳鐨勯珮鍗变汉缇ゃ€傚彲杩欏苟闈炵瀛︾殑渚涜嵂浼樺厛绾у埆鎺掑簭銆傚悎鐞嗙殑渚涚粰鎺掑簭鏄鍦ㄤ繚闅滄渶闇€瑕佺殑鎮ｈ€呮嬁鍒拌嵂鐨勫悓鏃剁‘淇濊嵂鐗╁湪浠栵紙濂癸級韬笂鑳藉彂鎸ユ渶澶т綔鐢ㄣ€備綔涓烘劅鏌撳悗瓒婃棭浣跨敤瓒婂ソ鐨勬姉鐥呮瘨鑽紝Paxlovid搴旇璁╅珮鍗变汉缇ゅ敖蹇敤涓婏紝鑰屼笉鏄瓑鍒汉鐥呭嚑澶╁悗锛屽湪楂樺嵄浜虹兢閲岀湅鐫€鏇村嵄闄╀簡涓€浜涘啀鐢ㄣ€?/p>
鎬讳箣锛岄潰瀵瑰ぇ閲忔劅鏌撶殑鍒版潵锛屾垜浠渶瑕佽Paxlovid鎴愪负绉戝闃茬柅浣撶郴涓殑涓€閮ㄥ垎锛岃€岄潪娓哥鍦ㄥ鐨勭綉涓婅喘鐗╁晢鍝佷箣涓€銆傝€岃繖涔熸湁鐫€宸ㄥぇ鐨勬€ヨ揩鎬э紝鐤儏楂樹綅鏃舵湡锛岀瀛﹂槻鐤綋绯荤己澶辩殑姣忎竴绉掗挓鑳屽悗锛屽彲鑳介兘鏄竴涓湰鍙尳鏁戠殑鐢熷懡锛屼竴娆℃湰鍙伩鍏嶇殑浣忛櫌銆?/p>
聽鍙傝€冩枃鐚細锛堜笂涓嬫粦鍔ㄥ彲娴忚锛?/p>
1.https://www.nejm.org/doi/full/10.1056/NEJMoa2118542
2.https://www.nejm.org/doi/full/10.1056/NEJMoa2204919
3.https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-oral-antiviral-treatment-covid-19
4.https://www.covid19treatmentguidelines.nih.gov/management/clinical-management-of-adults/nonhospitalized-adults--therapeutic-management/
5.https://www.fiercepharma.com/pharma/jpm-2022-pfizer-bumps-paxlovid-production-estimate-to-120-million-for-year-while-also
6.https://www.covid19treatmentguidelines.nih.gov/overview/prioritization-of-therapeutics/
7.https://aspr.hhs.gov/TestToTreat/Pages/default.aspx
8.https://aspr.hhs.gov/COVID-19/Therapeutics/Orders/Pages/default.aspx
鍒剁増缂栬緫聽|聽鏉句华
