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銆婅嚜鐒堵峰尰瀛︺€嬪彂甯冮噸纾呮垚鏋滐紒ctDNA鍙湁鏁堥娴嬮潪灏忛
更新时间:2022-11-14

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鍦ㄥ緱鍒版祴搴忕粨鏋滃悗锛屽叡鏈?18渚嬶紙37%锛夋偅鑰呮帴鍙椾簡闈跺悜娌荤枟锛屽叾涓?55渚嬶紙23%锛夌粡ctDNA鍖归厤锛?63渚嬶紙14%锛夌粡缁勭粐娴嬪簭鍖归厤銆?strong>鎵€鏈夋帴鍙楅澏鍚戞不鐤楃殑鎮h€呬腑锛屽彲妫€娴嬪埌ctDNA鐨凮S杈冧綆锛岀粡ctDNA鍖归厤鍒伴澏鍚戞不鐤楃殑鎮h€呯浉姣旀湭鎺ュ彈闈跺悜娌荤枟鐨勶紝OS鎻愰珮锛圚R=0.63锛宲锛?.001锛夛紝鑰?strong>鏈娴嬪埌ctDNA鐨勶紝鏄惁鎺ュ彈闈跺悜娌荤枟涓嶅奖鍝峅S銆?/strong>

杩欒〃鏄庯紝鍦╟tDNA闃虫€х殑鎮h€呬腑锛岄澏鍚戞不鐤楀叿鏈夋洿澶х殑鐩稿鑾风泭銆?/strong>

429渚嬪湪ctDNA娴嬪簭鍚?0澶╁唴鎺ュ彈缁勭粐娴嬪簭鐨勬偅鑰呬腑锛?09渚嬶紙25%锛夊彧鍦╟tDNA娴嬪簭涓娴嬪埌绐佸彉鎴栨嫹璐濇暟鍙樺寲锛屽叾涓湁3渚嬩负EGFRT790M绐佸彉锛屾偅鑰呭洜姝よ浆鎹㈡不鐤楋紝鍏朵粬鍙澏鍚戠獊鍙樿繕鍖呮嫭1渚婯RASG12C绐佸彉銆?渚婤RAFV600E绐佸彉鍜?渚婻ET铻嶅悎锛屼絾娌℃湁杞崲娌荤枟銆?/p>

杩欑浠呭叿鏈塩tDNA妫€娴嬪埌鐨勫彉寮傜殑鎮h€咃紝鐩告瘮鍏锋湁鍚屾椂鑳藉琚玞tDNA鍜岀粍缁囨祴搴忔娴嬪埌鐨勫彉寮傜殑鎮h€咃紝OS闄嶄綆锛屾棤璁烘槸绐佸彉杩樻槸鎷疯礉鏁板彉鍖栵紝缁撴灉閮芥槸涓€鑷寸殑銆傝繖琛ㄦ槑锛屼粎ctDNA鑳芥娴嬪埌鐨勫彉寮備篃鏄緝涓哄父瑙佺殑锛屽苟涓斿悓鏍峰叿鏈夐娴嬮鍚庣殑浠峰€笺€?/p>

浠卌tDNA妫€娴嬪埌鍙樺紓鐨勬偅鑰咃紙绱級涓巆tDNA鍜岀粍缁囨祴搴忓潎妫€娴嬪埌鍙樺紓鐨勬偅鑰咃紙钃濓級鐨凮S

鐮旂┒浜哄憳鍙戠幇鐨勪粎ctDNA妫€娴嬪埌鐨勫彉寮傚叾瀹炰篃鏄粍缁囦腑鐨勫父瑙佸彉寮傦紝杩欎簺鍙樺紓涓紝缁у彂鎬ц€愯嵂鍩哄洜鐨勬瘮渚嬪緢楂橈紝灏ゅ叾鏄疪ICTOR銆丯TRK1銆丮ET鍜孍RBB2鎵╁鍜孭IK3CA绐佸彉銆?/p>

浠卌tDNA鍜岀粍缁囧彉寮備腑锛岃嚧鐥呮€у彉寮傜殑鍩哄洜姘村钩鐨勫垎甯?/p>

杩欎簺缁у彂鎬ц€愯嵂鍩哄洜鍙樺紓閫氬父涓庢洿绯熺硶鐨勯鍚庢湁鍏筹紝浣嗗垎鏋愮粨鏋滄樉绀猴紝妫€娴嬪埌鏈堿LK銆丷ET鍜孍GFR鍙樺紓鐨勬偅鑰呮湁杈冮珮鐨凮S锛屾湁STK11鍙樺紓鐨勬偅鑰呮湁杈冧綆鐨凮S锛岃€孯ICTOR銆丯TRK1銆丮ET鍜孍RBB2鍜孭IK3CA鍙樺紓涓庤緝浣庣殑OS娌℃湁鍏宠仈銆傝繖琛ㄦ槑锛?strong>ctDNA-缁勭粐娴嬪簭缁撴灉鐨勫樊寮傛槸涓€涓叧閿鍚庡洜绱狅紝鑰屼笉鏄熀鍥犵粍鍙樺紓銆?/strong>

鎬荤殑鏉ョ湅锛岃繖椤圭爺绌惰〃鏄庯紝ctDNA涓€鏂归潰鍙互鎸囧NSCLC鎮h€呯殑闈跺悜娌荤枟鐢ㄨ嵂锛屾敼鍠勬偅鑰呴鍚庯紝鍙︿竴鏂归潰杩樺彲浠ヤ綔涓轰竴涓嫭绔嬬殑OS棰勬祴鍥犵礌锛屽畠鏄偪鐦ゅ井杞Щ鎴栬偪鐦や镜琚€у鍔犵殑鏍囧織锛屽湪璇勪及绯荤粺鎬ф不鐤楀悗鐨勭柧鐥呰礋鎷呭拰澶嶅彂椋庨櫓鏃讹紝鍙笌鏀惧皠鎬ф鏌ョ粨鏋滅粨鍚堛€?/p>

褰撶劧锛岃繖浜涚粨鏋滀篃缁欑爺绌朵汉鍛樻彁鍑轰簡鏂扮殑闂锛屾瘮濡傦紝涓轰粈涔坈tDNA闃存€х殑鎮h€匫S鏇撮珮锛熸槸鍥犱负浠栦滑鐨勮偪鐦ゅ娈栫紦鎱㈠悧锛熸槸鍚︿笌褰卞搷鑽墿鎽勫彇鐨勮偪鐦ゅ井鐜鐗瑰畾鐗瑰緛鏈夊叧锛熸垜浠兘鍚﹂€氳繃鑽墿灏哻tDNA闃虫€ц浆鍙樹负闃存€э紵杩欎簺闂闇€瑕佸熀浜巆tDNA鍔ㄥ姏瀛︼紝鍒嗗埆浠庤偪鐦ゅ拰鎮h€呭叆鎵嬶紝鏉ラ槓鏄庡叾涓殑涓村簥鍜岀敓鐗╁鏈哄埗[5]銆?/p>

鍙傝€冩枃鐚細

[1] Bruno D S, Hess L M, Li X, et al. Racial disparities in biomarker testing and clinical trial enrollment in non-small cell lung cancer (NSCLC)[J]. J Clin Oncol, 2021.

[2] Robert N J, Nwokeji E D, Espirito J L, et al. Biomarker tissue journey among patients (pts) with untreated metastatic non-small cell lung cancer (metastatic NSCLC) in the US Oncology Network community practices[J]. J Clin Oncol, 2021, 39.

[3] Zugazagoitia J, Ramos I, Trigo J M, et al. Clinical utility of plasma-based digital next-generation sequencing in patients with advance-stage lung adenocarcinomas with insufficient tumor samples for tissue genotyping[J]. Annals of Oncology, 2019, 30(2): 290-296.

鏈枃浣滆€呬辅搴旈洦濡?/p>

关键词:銆婅,嚜鐒,堵峰,尰瀛,︺,€,嬪彂,甯冮,噸纾,
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