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褰撶爺绌朵汉鍛樼粰浜堢己涔忎机瀹虫劅鍙楀櫒鐨勫皬榧燙GRP鍚庯紝灏忛紶鑲犻亾鐨勭矘娑擦垎娉岃繀閫熷鍔犮€傚嵆浣垮湪浼ゅ鎰熷彈鍣ㄧ己澶辩殑鎯呭喌涓嬶紝杩欑娌荤枟涔熻兘淇濇姢鍔ㄧ墿鍏嶅彈缁撹偁鐐庣殑渚靛銆傝繖涓€鍙戠幇琛ㄦ槑锛?strong>CGRP鏄鑷翠繚鎶ゆ€х矘娑擦垎娉屼俊鍙风骇鑱斿弽搴旂殑鍏抽敭鍒烘縺鍥犲瓙銆?/strong>
鎬讳箣锛岃繖浜涘彂鐜拌〃鏄庯紝浼ゅ鎰熷彈鍣ㄧ缁忓厓鍙婂叾閫氳繃CGRP-Ramp1杞村悜鏉姸缁嗚優鍙戝嚭淇″彿鍦ㄨ偁閬撳睆闅滀繚鎶や腑鍙戞尌鐫€鍏抽敭浣滅敤銆?/strong>鍥犳锛屼笌妫€娴嬫綔鍦ㄤ机瀹冲苟鍚戝ぇ鑴戝彂閫佷俊鍙风殑缁忓吀宸ヤ綔鐩告瘮锛岀柤鐥涘彲鑳戒互鏇寸洿鎺ョ殑鏂瑰紡鍦ㄤ繚鎶ょ潃鎴戜滑銆傝繖鎰忓懗鐫€绁炵粡绯荤粺鍦ㄨ偁閬撲腑鐨勪富瑕佷綔鐢ㄤ笉浠呬粎鏄粰鎴戜滑甯︽潵涓嶆剦蹇殑鎰熻锛屽畠涔熸槸鑲犻亾灞忛殰缁存姢鐨勫叧閿鑹诧紝浠ュ強鐐庣棁鏈熼棿鐨勪繚鎶ゆ満鍒躲€?/p> 璁烘枃閾炬帴锛?/strong> https://doi.org/10.1016/j.cell.2022.09.024
