鈻庤嵂鏄庡悍寰峰唴瀹瑰洟闃熺紪杈?/p>
浠婃棩涓氱晫浼犳潵涓€椤归噸纾呮秷鎭紝鐢遍粯娌欎笢锛圡SD锛変笌Moderna鑱斿悎寮€鍙戠殑涓綋鍖栫檶鐥囩柅鑻梞RNA-4157/V940涓嶱D-1鎶戝埗鍓侹eytruda鐨勭粍鍚堢枟娉曪紝鍦ㄤ复搴?b鏈熻瘯楠屽綋涓樉绀猴紝涓嶬eytruda鍗曡嵂娌荤枟鐩告瘮锛屽彲浠ユ樉钁楅檷浣嶪II銆両V鏈熼粦鑹茬礌鐦ゆ偅鑰呭湪鑲跨槫瀹屽叏鍒囬櫎鍚庣殑澶嶅彂鎴栨浜￠闄╄揪44%锛?/strong>鏍规嵁鏂伴椈绋匡紝杩欐槸棣栨mRNA鐤嫍鍦ㄩ殢鏈轰复搴婅瘯楠屽綋涓睍鐜版不鐤楅粦鑹茬礌鐦ょ殑鏁堝姏銆傛牴鎹椤圭Н鏋佺粨鏋滐紝涓ゅ鍏徃灏嗕笌鐩戠鍗曚綅璁ㄨ璇曢獙缁撴灉锛?strong>璁″垝浜庢槑骞村惎鍔ㄥ湪榛戣壊绱犵槫鎮ｈ€呯殑涓村簥3鏈熻瘯楠屽苟灏嗘缁勫悎鐤楁硶鎵╁睍搴旂敤鑷冲叾浠栬偪鐦ょ被鍨嬨€?/strong>
鐧岀棁鐤嫍鍙ぇ鑷村垎涓轰袱绫伙細棰勯槻鎬х柅鑻椾笌娌荤枟鎬х柅鑻椼€傞闃叉€х檶鐥囩柅鑻椾富瑕侀拡瀵圭殑鏄梾姣掓劅鏌撳鑷寸殑鐧岀棁銆備緥濡傞€氳繃闃绘浜轰钩澶寸槫鐥呮瘨鎴栦箼鍨嬭倽鐐庣梾姣掓劅鏌擄紝鍙互棰勯槻杩欎袱绫荤梾姣掑鑷寸殑鐧岀棁銆傝€屽彟涓€绫讳负娌荤枟鎬х檶鐥囩柅鑻楋紝涔熷氨鏄府鍔╄偪鐦ゆ偅鑰呭埡婵€鍏嶇柅绯荤粺鏉ヨ幏寰楁洿寮虹殑鎶楃檶鑳藉姏銆傝繖浜涚柅鑻椾細浠ヨ偪鐦ょ粏鑳炶〃杈剧殑鐗瑰畾琛ㄩ潰铔嬬櫧涓虹洰鏍囷紝甯姪鍏嶇柅绯荤粺璇嗗埆杩欎簺铔嬬櫧锛屼篃灏辨槸鑲跨槫鎶楀師銆傝€?strong>涓綋鍖栫檶鐥囩柅鑻楃殑鐩殑鏄€氳繃鏍规嵁鎮ｈ€呬釜浣撳寲鑲跨槫绐佸彉绫诲埆璁捐鐨勭柅鑻楋紝鍙府鍔╂偅鑰呬骇鐢熺浉瀵瑰簲鐨勬姉鑲跨槫鍙嶅簲锛岃繘鑰屾彁鍗囩檶鐥囨偅鑰呯殑鍏嶇柅鑳藉姏銆?/strong>
榛戣壊绱犵槫鏄瀬鍏惰嚧鍛界殑鐨偆鐧岀被鍨嬶紝鍏剁壒寰佹槸鍦ㄦ甯哥毊鑲ゆ垨鍘熸湁鐨勭棧涓婏紝鑹茬礌鐢熸垚缁嗚優鐨勭敓闀垮け鎺э紝閫犳垚鐨偆涓婂嚭鐜颁笉瑙勫垯鎵佸钩鎴栭殕璧风殑鏂戝潡锛屼即鏈夐鑹蹭笉鍖€鐨勬枒鐐规垨鍧氬疄鐨勯粦鐏拌壊鑲垮潡銆傚湪杩囧幓鍑犲崄骞翠腑锛岄粦鑹茬礌鐦ょ殑鍙戠梾鐜囦竴鐩村湪涓婂崌锛屽湪2020骞村叏涓栫晫鏂扮‘璇婄殑榛戣壊绱犵槫鎮ｈ€呰揪鍒?2.5涓囥€傛嵁棰勪及锛孖II銆両V鏈熼粦鑹茬礌鐦ゆ偅鑰呯殑5骞村瓨娲荤巼鍒嗗埆涓?0.3%涓?6.2%銆?/p>
鈻睲oderna涓綋鍖栫檶鐥囩柅鑻楄璁★紙鍥剧墖鏉ユ簮锛氬弬鑰冭祫鏂橻3]锛?/p>
Moderna涓庨粯娌欎笢鎵€寮€鍙戠殑鍦ㄧ爺mRNA-4157/V940鐧岀棁鐤嫍鍖呭惈缂栫爜鏈€澶?4绉嶆柊鎶楀師鐨勫崟涓€鍚堟垚mRNA鍒嗗瓙锛岃繖浜涙柊鎶楀師鏄牴鎹瘡浣嶆偅鑰呰偪鐦ょ嫭鐗圭殑DNA搴忓垪绐佸彉鐗瑰緛閫氳繃婕旂畻娉曟墍璁捐鑰屾垚銆?/strong>褰撳皢姝ょ檶鐥囩柅鑻楁敞灏勫叆浣撳唴鏃讹紝杩欎簺RNA鎵€鎼哄甫鐨勬柊鎶楀師搴忓垪浼氳缈昏瘧鎴愯泲鐧借川锛屽苟閫氳繃浣撳唴鐨勬姉鍘熷憟閫掞紝鍒烘縺浜х敓T缁嗚優鎶楄偪鐦ゅ弽搴斻€?strong>鑷幏寰楄偪鐦ゆ牱鏈嚦瀵圭梾鎮ｈ繘琛屾不鐤楋紝绾﹂渶鑺辫垂45澶╃殑鏃堕棿锛屼袱瀹跺叕鍙镐粛缁х画灏濊瘯缂╃煭姝よ繃绋嬫墍闇€鏃堕棿銆?/strong>Moderna涓庨粯娌欎笢鑷?016骞翠究鐫€鎵嬭繘琛屾鐧岀棁鐤嫍椤圭洰锛屽苟鍦?/p> 浠婂勾10鏈堝甯?/p> 缁х画浠栦滑鐨勫悎浣滐紝鍏卞悓寮€鍙戜笌鍟嗕笟鍖栨鐧岀棁鐤嫍銆?/p> 鍦ㄨ繖娆℃墍鍏竷鐨凨EYNOTE-942/mRNA-4157-P201璇曢獙锛屾槸涓€椤瑰紑鏀炬爣绛剧殑涓村簥2b鏈熻瘯楠岋紝鍏辨湁157浣嶆偅鑰呭叆缁勩€傛暟鎹垎鏋愭樉绀猴紝涓嶬eytruda鍗曡嵂娌荤枟鐩告瘮锛岀檶鐥囩柅鑻椾笌Keytruda鍦↖II銆両V鏈熼粦鑹茬礌鐦ゆ偅鑰呰繘琛岃偪鐦ゅ畬鍏ㄥ垏闄ゅ悗锛?strong>鍙湪缁熻涓婃樉钁楀苟鍏蜂复搴婃剰涔夊湴鏀瑰杽璇曢獙涓昏缁堢偣鏃犲鍙戠敓瀛樻湡锛圧FS锛夈€?/strong>姝ょ粍鍚堢枟娉曞彲闄嶄綆鎮ｈ€呭鍙戞垨姝讳骸椋庨櫓杈?4%锛圚R锛?.56锛?5% CI锛?.31-1.08锛屽崟渚鍊?0.0266锛夈€?/strong>
鍥剧墖鏉ユ簮锛?23RF
瀹夊叏鎬ф柟闈篃涓庤繃鍘昏瘯楠屼竴鑷达紝鍦ㄧ粍鍚堢枟娉曚笌Keytruda鍗曡嵂娌荤枟缁勪腑鎵€瑙佷骇鐢熶弗閲嶆不鐤楃浉鍏充笉鑹弽搴旀瘮鐜囧垎鍒负14.4%涓?0%銆?/p>
Moderna鐨勯甯墽琛屽畼St茅phane Bancel鍏堢敓鍦ㄦ帴鍙楄涓氬獟浣揈ndpoints News鏃舵彁鍒帮紝姝RNA鐧岀棁鐤嫍涓庡叾寮€鍙戠殑鏂板啝鐥呮瘨鐤嫍鎵€浣跨敤鐨勭鎶€鐩稿悓锛屽洜姝ゅ叾瀹夊叏鎬у凡缁忚繃涓€瀹氱▼搴︾殑楠岃瘉銆?/strong>姝ゅ锛岄櫎浜嗕笌榛樻矙涓滃叡鍚屽皢姝ょ粍鍚堢枟娉曟帹骞胯嚦鍚勭被鐧岀棁娌荤枟澶栵紝Moderna浜︽墦绠楁瑙嗘鐧岀棁鐤嫍浣滀负鍗曡嵂鐤楁硶鐨勬晥鍔涖€?/p> 鈥滀粖鏃ュ叕甯冪殑缁撴灉瀵逛簬鐧岀棁娌荤枟棰嗗煙鑰岃█鏄护浜烘劅鍒伴紦鑸炵殑锛宮RNA宸擦湪鎺у埗鏂板啝鐥呮瘨涓婂甫鏉ラ潻鍛芥€х殑褰卞搷锛?strong>鑰岃繖鏄娆℃垜浠睍绀簃RNA鍦ㄩ粦鑹茬礌鐦ら殢鏈轰复搴婅瘯楠屽綋涓叿鏈夋綔鍦ㄦ晥鍔涳紝
Moderna涓庨粯娌欎笢浠嶄笓娉ㄤ簬鐧岀棁鐤嫍鍐呴澏鐐圭殑鏀瑰杽锛屽寘鍚拡瀵归偅浜涚檶缁嗚優琛ㄩ潰涓婂厤鐤郴缁熼毦浠ヨ鲸璁ょ殑铔嬬櫧锛屼互鍙婂彂鐜拌澶氱梾鎮ｅ叡鍚屾嫢鏈夌殑绐佸彉缁勪互寮€鍙戞垚涓烘爣鍑嗙枟娉曘€?/p>
鍙傝€冭祫鏂欙細
[1] Moderna and Merck Announce mRNA-4157/V940, an Investigational Personalized mRNA Cancer Vaccine, in Combination With KEYTRUDA庐 (pembrolizumab), Met Primary Efficacy Endpoint in Phase 2b KEYNOTE-942 Trial. Retrieved December 13, 2022 from https://www.merck.com/news/moderna-and-merck-announce-mrna-4157-v940-an-investigational-personalized-mrna-cancer-vaccine-in-combination-with-keytruda-pembrolizumab-met-primary-efficacy-endpoint-in-phase-2b-keynote-94/
[2] Updated: Moderna claims cancer vaccine success in trial of mRNA shot with Merck. Retrieved December 13, 2022 from https://endpts.com/moderna-claims-cancer-vaccine-success-in-trial-of-mrna-shot-with-merck/
[3]Annual R&D Day. Retrieved October 12, 2022fromhttps://s29.q4cdn.com/435878511/files/doc_presentations/2022/09/Moderna-Final-R-D-Day-Slides_PDF-(09.08.22).pdf
